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Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
Effects of in vivo conditions on amyloid aggregation
One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …
govern protein misfolding and aggregation, which is a highly complex process that is …
[HTML][HTML] Computer-aided nanodrug discovery: recent progress and future prospects
JJ Zheng, QZ Li, Z Wang, X Wang, Y Zhao… - Chemical Society …, 2024 - pubs.rsc.org
Nanodrugs, which utilise nanomaterials in disease prevention and therapy, have attracted
considerable interest since their initial conceptualisation in the 1990s. Substantial efforts …
considerable interest since their initial conceptualisation in the 1990s. Substantial efforts …
Fluorescent probes for bioimaging of potential biomarkers in Parkinson's disease
Parkinson's disease (PD), as the second most common neurodegenerative disease, is
caused by complex pathological processes and currently remains very difficult to treat. PD …
caused by complex pathological processes and currently remains very difficult to treat. PD …
Physics-based computational and theoretical approaches to intrinsically disordered proteins
Highlights•Liquid-liquid phase separation underlies the formation of membraneless
organelles within cells.•Theory and molecular simulations help to relate interactions at the …
organelles within cells.•Theory and molecular simulations help to relate interactions at the …
Bioinspired crowding directs supramolecular polymerisation
Crowding effects are crucial to maintaining functionality in biological systems, but little is
known about their role in analogous artificial counterparts. Within the growing field of …
known about their role in analogous artificial counterparts. Within the growing field of …
Crowding in cellular environments at an atomistic level from computer simulations
The effects of crowding in biological environments on biomolecular structure, dynamics, and
function remain not well understood. Computer simulations of atomistic models of …
function remain not well understood. Computer simulations of atomistic models of …
Disorder-to-order transition of the amyloid-β peptide upon lipid binding
There is mounting evidence that Alzheimer's disease progression and severity are linked to
neuronal membrane damage caused by aggregates of the amyloid-β (A β) peptide …
neuronal membrane damage caused by aggregates of the amyloid-β (A β) peptide …
[HTML][HTML] Amyloid growth and membrane damage: Current themes and emerging perspectives from theory and experiments on Aβ and hIAPP
Alzheimer's Disease (AD) and Type 2 diabetes mellitus (T2DM) are two incurable diseases
both hallmarked by an abnormal deposition of the amyloidogenic peptides Aβ and Islet …
both hallmarked by an abnormal deposition of the amyloidogenic peptides Aβ and Islet …
Amyloid-β peptide dimers undergo a random coil to β-sheet transition in the aqueous phase but not at the neuronal membrane
Mounting evidence suggests that the neuronal cell membrane is the main site of oligomer-
mediated neuronal toxicity of amyloid-β peptides in Alzheimer's disease. To gain a detailed …
mediated neuronal toxicity of amyloid-β peptides in Alzheimer's disease. To gain a detailed …