Radiomics, the high-throughput mining of quantitative image features from standard-of-care
medical imaging that enables data to be extracted and applied within clinical-decision …

Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs
used daily in oncology include clinical TNM stage, objective response and left ventricular …

Background For virtually every patient with colorectal cancer (CRC), hematoxylin–eosin
(HE)–stained tissue slides are available. These images contain quantitative information …

Tumors exhibit genomic and phenotypic heterogeneity, which has prognostic significance
and may influence response to therapy. Imaging can quantify the spatial variation in …

With the emergence of individualized medicine and the increasing amount and complexity of
available medical data, a growing need exists for the development of clinical decision …

The development and implementation of quantitative imaging biomarkers has been
hampered by the inconsistent and often incorrect use of terminology related to these …

The Tofts model (TM) and extended Tofts model (ETM) have become a standard for the
analysis of dynamic contrast‐enhanced MRI. In this study, a mathematical analysis is used …

Hypoxia is known to be a poor prognostic indicator for nearly all solid tumours and also is
predictive of treatment failure for radiotherapy, chemotherapy, surgery and targeted …

Purpose: We established a CT-derived approach to achieve accurate progression-free
survival (PFS) prediction to EGFR tyrosine kinase inhibitors (TKI) therapy in multicenter …

Hematoxylin and eosin-stained biopsy slides are regularly available for colorectal cancer
patients. These slides are often not used to define objective biomarkers for patient …