The roles of tertiary lymphoid structures in chronic diseases

Y Sato, K Silina, M van den Broek, K Hirahara… - Nature Reviews …, 2023 - nature.com
Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that drive antigen-specific
immune responses at sites of chronic inflammation. Unlike secondary lymphoid organs such …

[HTML][HTML] Overview of the mechanisms of oxidative stress: impact in inflammation of the airway diseases

GD Albano, RP Gagliardo, AM Montalbano, M Profita - Antioxidants, 2022 - mdpi.com
Inflammation of the human lung is mediated in response to different stimuli (eg, physical,
radioactive, infective, pro-allergenic or toxic) such as cigarette smoke and environmental …

Human distal lung maps and lineage hierarchies reveal a bipotent progenitor

P Kadur Lakshminarasimha Murthy, V Sontake, A Tata… - Nature, 2022 - nature.com
Map** the spatial distribution and molecular identity of constituent cells is essential for
understanding tissue dynamics in health and disease. We lack a comprehensive map of …

Physiology and pathophysiology of human airway mucus

DB Hill, B Button, M Rubinstein… - Physiological …, 2022 - journals.physiology.org
The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

Gut microbiota modulates COPD pathogenesis: role of anti-inflammatory Parabacteroides goldsteinii lipopolysaccharide

HC Lai, TL Lin, TW Chen, YL Kuo, CJ Chang, TR Wu… - Gut, 2022 - gut.bmj.com
Objective Chronic obstructive pulmonary disease (COPD) is a global disease characterised
by chronic obstruction of lung airflow interfering with normal breathing. Although the …

Fruits, vegetables, and health: A comprehensive narrative, umbrella review of the science and recommendations for enhanced public policy to improve intake

TC Wallace, RL Bailey, JB Blumberg… - Critical reviews in …, 2020 - Taylor & Francis
Fruit and vegetables (F&V) have been a cornerstone of healthy dietary recommendations;
the 2015–2020 US Dietary Guidelines for Americans recommend that F&V constitute one …

Surface modification of lipid-based nanoparticles

Y Xu, T Fourniols, Y Labrak, V Préat, A Beloqui… - ACS …, 2022 - ACS Publications
There is a growing interest in the development of lipid-based nanocarriers for multiple
purposes, including the recent increase of these nanocarriers as vaccine components …

Update on the pathogenesis of chronic obstructive pulmonary disease

A Agustí, JC Hogg - New England Journal of Medicine, 2019 - Mass Medical Soc
Update on the Pathogenesis of Chronic Obstructive Pulmonary Disease | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

[HTML][HTML] Tobacco smoke induces and alters immune responses in the lung triggering inflammation, allergy, asthma and other lung diseases: a mechanistic review

A Strzelak, A Ratajczak, A Adamiec… - International journal of …, 2018 - mdpi.com
Many studies have been undertaken to reveal how tobacco smoke skews immune
responses contributing to the development of chronic obstructive pulmonary disease …

Characterization of the COPD alveolar niche using single-cell RNA sequencing

M Sauler, JE McDonough, TS Adams… - Nature …, 2022 - nature.com
Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide,
however our understanding of cell specific mechanisms underlying COPD pathobiology …