RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …

Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are
considered as specialized immune cells that can be genetically modified to obtain capable …

Viruses accumulate mutations under the influence of natural selection and host–virus
interactions. Through a systematic comparison of 351,525 full viral genome sequences …

Owing to a lag between a deleterious mutation's appearance and its selective removal, gold-
standard methods for mutation rate estimation assume no meaningful loss of mutations …

The genetic material of the three domains of life (Bacteria, Archaea, and Eukaryota) is
always double-stranded DNA, and their GC content (molar content of guanine plus cytosine) …

RNA viruses are responsible for some of the worst pandemics known to mankind, including
outbreaks of Influenza, Ebola, and COVID-19. One major challenge in tackling RNA viruses …

The pathogenesis of COVID-19 is still elusive, which impedes disease progression
prediction, differential diagnosis, and targeted therapy. Plasma cell-free RNAs (cfRNAs) …

As the SARS-CoV-2 pandemic is rapidly progressing, the need for the development of an
effective vaccine is critical. A promising approach for vaccine development is to generate …

Goose astroviruses (GoAstVs) are causative agents that account for fatal infection of
goslings characterized by visceral urate deposition, resulting in severe economic losses in …

The phenotypic consequence of a genetic mutation depends on many factors including the
expression level of a gene. However, a comprehensive quantification of this expression …