Regulation through post‐translational ubiquitin signaling underlies a large portion of
eukaryotic biology. This has not gone unnoticed by invading pathogens, many of which have …

Reactive aldehydes are produced by normal cellular metabolism or after alcohol
consumption, and they accumulate in human tissues if aldehyde clearance mechanisms are …

Aspects of how Burkholderia escape the host's intrinsic immune response to replicate in the
cell cytosol remain enigmatic. Here, we show that Burkholderia has evolved two …

The study of virulence of Legionella pneumophila and its interactions with its hosts has been
predominantly conducted in cellulo in the past decades. Although easy to implement and …

Besides the regulation of many cellular pathways, ubiquitination is important for defense
against invading pathogens. Some intracellular bacteria have evolved deubiquitinase (DUB) …

Legionella pneumophila utilizes the Dot/Icm type IVB secretion system to deliver hundreds
of effector proteins inside eukaryotic cells to ensure intracellular replication. Our …

Although ubiquitin is found only in eukaryotes, several pathogenic bacteria and viruses
possess proteins that hinder the host ubiquitin system. Legionella, a gram-negative …

The prevailing view on post-translational modifications (PTMs) is that a single amino acid is
modified with a single PTM at any given time. However, recent work has demonstrated …

Summary Homologous to E6AP C terminus (HECT) E3 ubiquitin (Ub) ligases direct
substrates toward distinct cellular fates dictated by the specific form of monomeric or …

Pathogenic bacteria have evolved diverse mechanisms to counteract cell-autonomous
immunity, which otherwise guards both immune and non-immune cells from the onset of an …