Porcine epidemic diarrhea virus: Molecular mechanisms of attenuation and vaccines

Z Li, Z Ma, Y Li, S Gao, S **ao - Microbial pathogenesis, 2020 - Elsevier
Porcine epidemic diarrhea virus (PEDV) causes an emerging and re-emerging coronavirus
disease characterized by vomiting, acute diarrhea, dehydration, and up to 100% mortality in …

Adjuvants for swine vaccines: Mechanisms of actions and adjuvant effects

W Charerntantanakul - Vaccine, 2020 - Elsevier
This review deals with mechanisms of actions (MOA) and adjuvant effects of various types of
adjuvants for swine vaccines. A number of different types of adjuvants have been tested with …

In situ structure and dynamics of an alphacoronavirus spike protein by cryo-ET and cryo-EM

CY Huang, P Draczkowski, YS Wang, CY Chang… - Nature …, 2022 - nature.com
Porcine epidemic diarrhea (PED) is a highly contagious swine disease caused by porcine
epidemic diarrhea virus (PEDV). PED causes enteric disorders with an exceptionally high …

Identification of neutralizing monoclonal antibodies targeting novel conformational epitopes of the porcine epidemic diarrhoea virus spike protein

CY Chang, IC Cheng, YC Chang, PS Tsai, SY Lai… - Scientific reports, 2019 - nature.com
Since 2010, newly identified variants of porcine epidemic diarrhoea virus (PEDV) have
caused high mortality in neonatal piglets which has devastated the swine industry. The spike …

Design of a native-like secreted form of the hepatitis C virus E1E2 heterodimer

JD Guest, R Wang, KH Elkholy… - Proceedings of the …, 2021 - National Acad Sciences
Hepatitis C virus (HCV) is a major worldwide health burden, and a preventive vaccine is
needed for global control or eradication of this virus. A substantial hurdle to an effective HCV …

Intranasally inoculated bacterium-like particles displaying porcine epidemic diarrhea virus S1 protein induced intestinal mucosal immune response in mice

K Su, Y Wang, C Yuan, Y Zhang, Y Li, T Li… - Frontiers in …, 2023 - frontiersin.org
Porcine epidemic diarrhea virus (PEDV) causes acute watery diarrhea and high mortality in
newborn piglets. Activation of intestinal mucosal immunity is crucial to anti-PEDV infection …

Display of porcine epidemic diarrhea virus spike protein on baculovirus to improve immunogenicity and protective efficacy

CY Chang, WT Hsu, YC Chao, HW Chang - Viruses, 2018 - mdpi.com
A new variant of the porcine epidemic diarrhea virus (PEDV) is an emerging swine disease,
killing considerable numbers of neonatal piglets in North America and Asia in recent years …

Immunogenicity and protective efficacy of a trimeric full-length S protein subunit vaccine for porcine epidemic diarrhea virus

W Guo, C Wang, X Song, H Xu, S Zhao, J Gu, Z Zou… - Vaccine, 2024 - Elsevier
Porcine epidemic diarrhea virus (PEDV) has caused serious economic losses to the pig
husbandry worldwide, and the effects of existing commercialized vaccines are suboptimal …

Efficacy of porcine epidemic diarrhea vaccines: A systematic review and meta-analysis

H Won, J Lim, YH Noh, I Yoon, HS Yoo - Vaccines, 2020 - mdpi.com
Porcine epidemic diarrhea (PED) is a devastating disease that causes considerable
economic damage to the global pig industry. Although the causative agent, the porcine …

Development and comparison of enzyme-linked immunosorbent assays based on recombinant trimeric full-length and truncated spike proteins for detecting …

CY Chang, JY Peng, YH Cheng, YC Chang… - BMC veterinary …, 2019 - Springer
Background Since 2010, outbreaks of genotype 2 (G2) porcine epidemic diarrhea virus
(PEDV) have caused high mortality in neonatal piglets and have had devastating impacts on …