The PEA3 subfamily is a subgroup of the E26 transformation-specific (ETS) family. Its
members, ETV1, ETV4, and ETV5, have been found to be overexpressed in multiple …

Simple Summary The composite network of stromal, immune, vascular and cancer cells,
which constitutes the tumor microenvironment (TME), has emerged as a player in thyroid …

Background: The BRAFV600E mutation is the most common driver mutation in papillary
thyroid cancer (PTC) and anaplastic thyroid cancer (ATC). This mutation is considered …

Simple Summary We identified an acquired RAC1 (P34R) mutation in the metastatic tumor
of a BRAF-mutated papillary thyroid cancer patient treated with the BRAF inhibitor …

In our previous study, ETV5 mediated-angiogenesis was demonstrated to be dependent
upon the PDGF-BB/PDGFR-β/Src/STAT3/VEGFA pathway in colorectal cancer (CRC) …

Background: Co-occurrence of TERT (telomerase reverse transcriptase) promoter (TERTp)
mutations with BRAF/RAS mutations is associated with significantly more aggressive thyroid …

Abstract Leucine‑rich‑alpha‑2‑glycoprotein 1 (LRG‑1) has been reported to be associated
with multiple malignancies. However, its participation in thyroid carcinoma progression …

Pancreatic ductal adenocarcinoma (PDAC) has the highest fatality rate of any solid tumor,
with a five-year survival rate of only 10% in the USA. PDAC is characterized by early …

ETS variant transcription factor 5 (ETV5), a master transcription factor during development,
exerts vital function on the occurrence and progression of various cancers. In order to …

Aims Thyroid cancer is a common endocrine malignancy and sex hormone plays an
important role in it. We have previously shown that activation of estrogen receptor (ER) α …