It is now appreciated that emerging therapeutic strategies for recovery must include the
cerebral vasculature and that induction of angiogenesis will stimulate endogenous recovery …

(1) Background: One mechanism through which physical activity (PA) provides benefits is by
triggering activity at a molecular level, where neurotrophins (NTs) are known to play an …

Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival and
growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity …

Abstract p75 neurotrophin receptor (p75NTR) signaling pathways substantially overlap with
degenerative networks active in Alzheimer disease (AD). Modulation of p75NTR with the first …

Autonomic cardiac neurons have a common origin in the neural crest but undergo distinct
developmental differentiation as they mature toward their adult phenotype. Progenitor cells …

Background Brain‐derived neurotrophic factor (BDNF) is a pleiotropic peptide involved in
maintaining endothelial integrity. It is unknown if circulating BDNF levels are associated with …

Neurotrophins (NTs) were first identified as target-derived survival factors for neurons of the
central and peripheral nervous system (PNS). They are known to control neural cell fate …

Rationale: Sympathetic stimulation of the heart increases the force of contraction and rate of
ventricular relaxation by triggering protein kinase (PK) A-dependent phosphorylation of …

Rationale: Nerve growth factor (NGF) promotes angiogenesis and cardiomyocyte survival,
which are both desirable for postinfarction myocardial healing. Nonetheless, the NGF …

Convergent evidence from human and non-human animal studies suggests aerobic
exercise and increased aerobic capacity may be beneficial for brain health and cognition. It …