Over the past decade, scientific discovery games (SDGs) have emerged as a viable
approach for biomedical research, engaging hundreds of thousands of volunteer players …

Motivation RNA design is the search for a sequence or set of sequences that will fold to
desired structure, also known as the inverse problem of RNA folding. However, the …

Computational RNA design tasks are often posed as inverse problems, where sequences
are designed based on adopting a single desired secondary structure without considering …

An RNA design algorithm takes a target RNA structure and finds a sequence that folds into
that structure. This is fundamentally important for engineering therapeutics using RNA …

Traditional RNA secondary structure prediction methods, based on dynamic programming,
often fall short in accuracy. Recent advances in deep learning have aimed to address this …

Functional design of ribosomes with mutant ribosomal RNA (rRNA) can expand
opportunities for understanding molecular translation, building cells from the bottom-up, and …

Solving the RNA inverse folding problem, also known as the RNA design problem, is critical
to advance several scientific fields like bioengineering, yet existing approaches have had …

ABSTRACT RNA is a crucial regulator in living organisms and malfunctions can lead to
severe diseases. To explore RNA-based therapeutics and applications, computational …

RNAs self-interact through hydrogen-bond base-pairing between nucleotides and fold into
specific, stable structures that substantially govern their biochemical behaviour …

Emerging RNA-based approaches to disease detection and gene therapy require RNA
sequences that fold into specific base-pairing patterns, but computational algorithms …