Meta-hallmarks of aging and cancer
Both aging and cancer are characterized by a series of partially overlap**" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …
Copper metabolism in cell death and autophagy
Copper is an essential trace element in biological systems, maintaining the activity of
enzymes and the function of transcription factors. However, at high concentrations, copper …
enzymes and the function of transcription factors. However, at high concentrations, copper …
Copper-dependent autophagic degradation of GPX4 drives ferroptosis
Ferroptosis is a type of iron-dependent regulated cell death characterized by unrestricted
lipid peroxidation and membrane damage. Although GPX4 (glutathione peroxidase 4) plays …
lipid peroxidation and membrane damage. Although GPX4 (glutathione peroxidase 4) plays …
Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer
J Li, J Liu, Z Zhou, R Wu, X Chen, C Yu… - Science translational …, 2023 - science.org
Lipid peroxidation–dependent ferroptosis has become an emerging strategy for tumor
therapy. However, current strategies not only selectively induce ferroptosis in malignant cells …
therapy. However, current strategies not only selectively induce ferroptosis in malignant cells …
GPX4 in cell death, autophagy, and disease
ABSTRACT Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …
The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis
Ferroptosis is a type of regulated necrosis caused by unrestricted lipid peroxidation and
subsequent plasma membrane rupture. However, the lipid remodeling mechanism that …
subsequent plasma membrane rupture. However, the lipid remodeling mechanism that …
Oxidative cell death in cancer: Mechanisms and therapeutic opportunities
Reactive oxygen species (ROS) are highly reactive oxygen-containing molecules generated
as natural byproducts during cellular processes, including metabolism. Under normal …
as natural byproducts during cellular processes, including metabolism. Under normal …
A guideline on the molecular ecosystem regulating ferroptosis
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid
peroxidation, has garnered substantial interest since this term was first coined in 2012 …
peroxidation, has garnered substantial interest since this term was first coined in 2012 …
Autophagy: Regulator of cell death
SZ Liu, SJ Yao, H Yang, SJ Liu, YJ Wang - Cell death & disease, 2023 - nature.com
Autophagy is the process by which cells degrade and recycle proteins and organelles to
maintain intracellular homeostasis. Generally, autophagy plays a protective role in cells, but …
maintain intracellular homeostasis. Generally, autophagy plays a protective role in cells, but …
A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis
X Chen, J Huang, C Yu, J Liu, W Gao, J Li… - Nature …, 2022 - nature.com
Ferroptosis is a type of lipid peroxidation-dependent cell death that is emerging as a
therapeutic target for cancer. However, the mechanisms of ferroptosis during the generation …
therapeutic target for cancer. However, the mechanisms of ferroptosis during the generation …