Presynaptic Ca2+ entry occurs through voltage-gated Ca2+ (CaV) channels which are
activated by membrane depolarization. Depolarization accompanies neuronal firing and …

Calcium is important in controlling nuclear gene expression through the activation of
multiple signal-transduction pathways in neurons. Compared with other voltage-gated …

Familial dysautonomia (FD), a rare neurodevelopmental and neurodegenerative disorder
affects the sympathetic and sensory nervous system. Although almost all patients harbor a …

Newly synthesized synaptic proteins and mitochondria are transported along lengthy
neuronal processes to assist in the proper assembly of develo** synapses and activity …

Acidification of synaptic vesicles by the vacuolar proton ATPase is essential for loading with
neurotransmitter. Debated findings have suggested that V-ATPase membrane domain (V0) …

Neurotransmitter release from presynaptic nerve terminals is regulated by soluble NSF
attachment protein receptor (SNARE) complex–mediated synaptic vesicle fusion. Tomosyn …

Autapse is an unusual type of synapse generated by a neuron on itself. The effect of autapse
connected to a neuron is often described by using a self-feedback forcing current in a close …

At the presynaptic terminal, neuronal firing activity induces membrane depolarization and
subsequent Ca 2+ entry through voltage-gated Ca 2+(Ca V) channels triggers …

An action potential (AP) triggers neurotransmitter release from synaptic vesicles (SVs)
docking to a specialized release site of presynaptic plasma membrane, the active zone (AZ) …

Synaptic vesicle glycoprotein (SV) 2A is a transmembrane protein found in secretory
vesicles and is critical for Ca2+‐dependent exocytosis in central neurons, although its …