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Retinal changes in Alzheimer's disease—integrated prospects of imaging, functional and molecular advances
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …
Visualizing cell death in experimental focal cerebral ischemia: promises, problems, and perspectives
One of the hallmarks of stroke pathophysiology is the widespread death of many different
types of brain cells. As our understanding of the complex disease that is stroke has grown, it …
types of brain cells. As our understanding of the complex disease that is stroke has grown, it …
A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion
Background Microglia cells continuously survey the healthy brain in a ramified morphology
and, in response to injury, undergo progressive morphological and functional changes that …
and, in response to injury, undergo progressive morphological and functional changes that …
Anti-glioblastoma efficacy and safety of paclitaxel-loading Angiopep-conjugated dual targeting PEG-PCL nanoparticles
Therapeutic effect of glioma is often limited due to low permeability of delivery systems
across the Blood-Brain Barrier (BBB) and poor penetration into the tumor tissue. In order to …
across the Blood-Brain Barrier (BBB) and poor penetration into the tumor tissue. In order to …
MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia
Abstract microRNA-124 (miR-124), the most abundant miRNA of the CNS, was recently
shown to modulate the polarization of activated microglia and infiltrating macrophages …
shown to modulate the polarization of activated microglia and infiltrating macrophages …
The impact of endothelial cell death in the brain and its role after stroke: a systematic review
The supply of oxygen and nutrients to the brain is vital for its function and requires a complex
vascular network that, when disturbed, results in profound neurological dysfunction. As part …
vascular network that, when disturbed, results in profound neurological dysfunction. As part …
Inhibition of cerebral ischemia/reperfusion injury-induced apoptosis: nicotiflorin and JAK2/STAT3 pathway
G Hu, X Du, Y Li, X Gao, B Chen… - Neural regeneration …, 2017 - journals.lww.com
Nicotiflorin is a flavonoid extracted from Carthamus tinctorius. Previous studies have shown
its cerebral protective effect, but the mechanism is undefined. In this study, we aimed to …
its cerebral protective effect, but the mechanism is undefined. In this study, we aimed to …
Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke
Background Subtle adjustment of the activation status of CNS resident microglia and
peripheral macrophages, to promote their neuroprotective and neuroregenerative functions …
peripheral macrophages, to promote their neuroprotective and neuroregenerative functions …
Amyloid precursor protein protects neuronal network function after hypoxia via control of voltage-gated calcium channels
D Hefter, M Kaiser, SW Weyer… - Journal of …, 2016 - jneurosci.org
Acute cerebral ischemia and chronic neurovascular diseases share various common
mechanisms with neurodegenerative diseases, such as disturbed cellular calcium and …
mechanisms with neurodegenerative diseases, such as disturbed cellular calcium and …
Monitoring Stroke Progression: In Vivo Imaging of Cortical Perfusion, Blood—Brain Barrier Permeability and Cellular Damage in the Rat Photothrombosis Model
K Schoknecht, O Prager, U Vazana… - Journal of Cerebral …, 2014 - journals.sagepub.com
Focal cerebral ischemia is among the main causes of death and disability worldwide. The
ischemic core often progresses, invading the peri-ischemic brain; however, assessing the …
ischemic core often progresses, invading the peri-ischemic brain; however, assessing the …