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Accelerating metabolite identification in natural product research: toward an ideal combination of liquid chromatography–high-resolution tandem mass spectrometry …
Natural product research aims to characterize specialized metabolites from various living
organisms and assess their biological properties from either a chemical ecology or drug …
organisms and assess their biological properties from either a chemical ecology or drug …
[HTML][HTML] How close are we to complete annotation of metabolomes?
Highlights•No exhaustive experimental characterisation of an organism's metabolome
reported.•Deep metabolome annotation strategies based on multi-platform …
reported.•Deep metabolome annotation strategies based on multi-platform …
Chemical discovery in the era of metabolomics
Untargeted metabolomics aims to quantify the complete set of metabolites within a biological
system, most commonly by liquid chromatography/mass spectrometry (LC/MS). Since nearly …
system, most commonly by liquid chromatography/mass spectrometry (LC/MS). Since nearly …
Nuclear magnetic resonance spectroscopy in clinical metabolomics and personalized medicine: current challenges and perspectives
Personalized medicine is probably the most promising area being developed in modern
medicine. This approach attempts to optimize the therapies and the patient care based on …
medicine. This approach attempts to optimize the therapies and the patient care based on …
Innovative omics-based approaches for prioritisation and targeted isolation of natural products–new strategies for drug discovery
Covering: 2013 to 2019 The exploration of the chemical diversity of extracts from various
biological sources has led to major drug discoveries. Over the past two decades, despite the …
biological sources has led to major drug discoveries. Over the past two decades, despite the …
Recent advances in targeted and untargeted metabolomics by NMR and MS/NMR methods
K Bingol - High-throughput, 2018 - mdpi.com
Metabolomics has made significant progress in multiple fronts in the last 18 months. This
minireview aimed to give an overview of these advancements in the light of their contribution …
minireview aimed to give an overview of these advancements in the light of their contribution …
Combined nuclear magnetic resonance spectroscopy and mass spectrometry approaches for metabolomics
Metabolomics is based on cutting-edge analytical methods that provide a “snapshot” of all
the detectable metabolites, small molecules generally weighing under 1200 Da, present in …
the detectable metabolites, small molecules generally weighing under 1200 Da, present in …
Use of untargeted metabolomics for assessing soil quality and microbial function
Soils support a wide range of ecosystem services that underpin Earth system functioning. It
is therefore essential that we have robust approaches to evaluate how anthropogenic …
is therefore essential that we have robust approaches to evaluate how anthropogenic …
[HTML][HTML] NMR as a “gold standard” method in drug design and discovery
Studying disease models at the molecular level is vital for drug development in order to
improve treatment and prevent a wide range of human pathologies. Microbial infections are …
improve treatment and prevent a wide range of human pathologies. Microbial infections are …
Recent advances in NMR-based metabolomics
NMR spectroscopy, one of the two major analytical platforms utilized in the metabolomics
field, has witnessed a large number of advances in fundamental studies, methods …
field, has witnessed a large number of advances in fundamental studies, methods …