Molecular regulations of circadian rhythm and implications for physiology and diseases
The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …
The circadian immune system
The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were
the first to identify immune responses to be under a circadian control. Only in the last …
the first to identify immune responses to be under a circadian control. Only in the last …
Clocking in to immunity
Circadian rhythms are a ubiquitous feature of virtually all living organisms, regulating a wide
diversity of physiological systems. It has long been established that the circadian clockwork …
diversity of physiological systems. It has long been established that the circadian clockwork …
The functional and clinical significance of the 24-hour rhythm of circulating glucocorticoids
Adrenal glucocorticoids are major modulators of multiple functions, including energy
metabolism, stress responses, immunity, and cognition. The endogenous secretion of …
metabolism, stress responses, immunity, and cognition. The endogenous secretion of …
Circadian control of the immune system
Circadian rhythms, which have long been known to play crucial roles in physiology, are
emerging as important regulators of specific immune functions. Circadian oscillations of …
emerging as important regulators of specific immune functions. Circadian oscillations of …
Circadian regulation of drug responses: toward sex-specific and personalized chronotherapy
Today's challenge for precision medicine involves the integration of the impact of molecular
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …
Circadian clocks in the immune system
N Labrecque, N Cermakian - Journal of biological rhythms, 2015 - journals.sagepub.com
The immune system is a complex set of physiological mechanisms whose general aim is to
defend the organism against non-self-bodies, such as pathogens (bacteria, viruses …
defend the organism against non-self-bodies, such as pathogens (bacteria, viruses …
Circadian clock proteins and immunity
Immune parameters change with time of day and disruption of circadian rhythms has been
linked to inflammatory pathologies. A circadian-clock-controlled immune system might allow …
linked to inflammatory pathologies. A circadian-clock-controlled immune system might allow …
Lymphocyte circadian clocks control lymph node trafficking and adaptive immune responses
D Druzd, O Matveeva, L Ince, U Harrison, W He… - Immunity, 2017 - cell.com
Lymphocytes circulate through lymph nodes (LN) in search for antigen in what is believed to
be a continuous process. Here, we show that lymphocyte migration through lymph nodes …
be a continuous process. Here, we show that lymphocyte migration through lymph nodes …
[HTML][HTML] Molecular interactions between components of the circadian clock and the immune system
S Hergenhan, S Holtkamp, C Scheiermann - Journal of molecular biology, 2020 - Elsevier
The immune system is under control of the circadian clock. Many of the circadian rhythms
observed in the immune system originate in direct interactions between components of the …
observed in the immune system originate in direct interactions between components of the …