The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …

The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were
the first to identify immune responses to be under a circadian control. Only in the last …

Circadian rhythms are a ubiquitous feature of virtually all living organisms, regulating a wide
diversity of physiological systems. It has long been established that the circadian clockwork …

Adrenal glucocorticoids are major modulators of multiple functions, including energy
metabolism, stress responses, immunity, and cognition. The endogenous secretion of …

Circadian rhythms, which have long been known to play crucial roles in physiology, are
emerging as important regulators of specific immune functions. Circadian oscillations of …

The immune system is a complex set of physiological mechanisms whose general aim is to
defend the organism against non-self-bodies, such as pathogens (bacteria, viruses …

Immune parameters change with time of day and disruption of circadian rhythms has been
linked to inflammatory pathologies. A circadian-clock-controlled immune system might allow …

Today's challenge for precision medicine involves the integration of the impact of molecular
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …

Lymphocytes circulate through lymph nodes (LN) in search for antigen in what is believed to
be a continuous process. Here, we show that lymphocyte migration through lymph nodes …

The sympathetic nervous system integrates the functions of multiple organ systems by
regulating their autonomic physiological activities. The immune system is regulated both …