It has recently become apparent that RNA, itself the product of transcription, is a major
regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs) …

First described in 1991, Yin Yang 1 (YY1) is a transcription factor that is ubiquitously
expressed throughout mammalian cells. It regulates both transcriptional activation and …

Yin Yang‐1 (YY1) is a zinc finger protein and member of the GLI‐Kruppel family that can
activate or inactivate gene expression depending on interacting partners, promoter context …

Summary Cys2-His2 zinc-finger proteins (C2H2-ZNFs) constitute the largest class of DNA-
binding transcription factors (TFs) yet remain largely uncharacterized. Although certain …

X-chromosome inactivation (XCI) in female lymphocytes is uniquely regulated, as the
inactive X (**) chromosome lacks localized **st RNA and heterochromatin modifications …

Neurodegenerative diseases (NDDs) are identified by the progressive deterioration of
neurons and a subsequent decline in cognitive function, creating an enormous burden on …

Metal ions are essential elements present in biological systems able to facilitate many
cellular processes including proliferation, signaling, DNA synthesis and repair. Zinc ion (Zn …

Glioblastoma multiforme (GBM) is the most malignant tumor of the central nervous system,
and chemoresistance blunts the effect of temozolomide (TMZ) in the treatment of GBM …

The largest group of transcription factors in higher eukaryotes are C2H2 proteins, which
contain C2H2‐type zinc finger domains that specifically bind to DNA. Few well‐studied …

Abstract Yin-Yang 1 (YY1) has been identified as playing critical roles in multiple diseases.
However, little is known regarding its roles and mechanisms in cerebral …