Since techniques for cardiomyocyte isolation were first developed 35years ago, experiments
on single myocytes have yielded great insight into their cellular and sub-cellular physiology …

Due to the increased morbidity and mortality resulting from heart valve diseases, there is a
growing demand for off-the-shelf implantable tissue engineered heart valves (TEHVs) …

Cultured neonatal cardiomyocytes have long been used to study myofibrillogenesis and
myofibrillar functions. Cultured cardiomyocytes allow for easy investigation and …

The availability of genetically altered cells is an essential prerequisite for many scientific and
therapeutic applications including functional genomics, drug development, and gene …

Background: Type 1 long QT syndrome (LQT1) is caused by loss-of-function variants in the
KCNQ1-encoded Kv7. 1 potassium channel α-subunit that is essential for cardiac …

Angiotensin converting enzyme 2 (ACE2), a newly discovered member of the renin–
angiotensin system (RAS), is a potential therapeutic target for the control of cardiovascular …

Systemic inhibition of miR-21 has proven effective against myocardial fibrosis and
dysfunction, while studies in cardiac myocytes suggested a protective role in this cell type …

In response to metabolic stress, GLUT4, the most abundant glucose transporter, translocates
from intracellular vesicles to the plasma membrane. This appears to play an important role in …

Gene therapy is a promising new treatment option for cardiac diseases. For finding the most
suitable and safe vector for cardiac gene transfer, we delivered adenovirus (AdV), adeno …

Aberrant Wnt signaling promotes oncogenesis by increasing cellular levels of β-catenin,
which associates with DNA-bound transcription factors and activates Wnt target genes …