Integrative modeling is an increasingly important tool in structural biology, providing
structures by combining data from varied experimental methods and prior information. As a …

Knowledge of protein structure is paramount to the understanding of biological function,
develo** new therapeutics, and making detailed mechanistic hypotheses. Therefore …

Cryoelectron microscopy requires molecular modeling for refinement of structures.
Ensemble models arrive at low free-energy molecular structures, but are computationally …

Cryogenic electron microscopy (cryo-EM) methods began to be used in the mid-1970s to
study thin and periodic arrays of proteins. Following a half-century of development in cryo …

This work builds upon the record-breaking speed and generous immediate release of new
experimental three-dimensional structures of the severe acute respiratory syndrome …

Cryo-EM is a powerful method for determining biomolecular structures. But, unlike X-ray
crystallography or solution-state NMR, which are data-rich, cryo-EM can be data-poor. Cryo …

Background the scientific training to become a bioinformatician includes multidisciplinary
abilities, which increase the challenges to professional development. Competition …

Motivation It has been a challenge for biologists to determine 3D shapes of proteins from a
linear chain of amino acids and understand how proteins carry out life's tasks. Experimental …