Tutorial: best practices and considerations for mass-spectrometry-based protein biomarker discovery and validation

ES Nakayasu, M Gritsenko, PD Piehowski, Y Gao… - Nature …, 2021 - nature.com
Mass-spectrometry-based proteomic analysis is a powerful approach for discovering new
disease biomarkers. However, certain critical steps of study design such as cohort selection …

Recent advances in mass spectrometry based clinical proteomics: applications to cancer research

A Macklin, S Khan, T Kislinger - Clinical proteomics, 2020 - Springer
Cancer biomarkers have transformed current practices in the oncology clinic. Continued
discovery and validation are crucial for improving early diagnosis, risk stratification, and …

Artificial intelligence in sepsis early prediction and diagnosis using unstructured data in healthcare

KH Goh, L Wang, AYK Yeow, H Poh, K Li… - Nature …, 2021 - nature.com
Sepsis is a leading cause of death in hospitals. Early prediction and diagnosis of sepsis,
which is critical in reducing mortality, is challenging as many of its signs and symptoms are …

Enhancing head and neck tumor management with artificial intelligence: Integration and perspectives

NN Zhong, HQ Wang, XY Huang, ZZ Li, LM Cao… - Seminars in cancer …, 2023 - Elsevier
Head and neck tumors (HNTs) constitute a multifaceted ensemble of pathologies that
primarily involve regions such as the oral cavity, pharynx, and nasal cavity. The intricate …

Advances in electrochemical biosensors based on nanomaterials for protein biomarker detection in saliva

T Dong, NM Matos Pires, Z Yang, Z Jiang - Advanced Science, 2023 - Wiley Online Library
The focus on precise medicine enhances the need for timely diagnosis and frequent
monitoring of chronic diseases. Moreover, the recent pandemic of severe acute respiratory …

PGK1-mediated cancer progression and drug resistance

Y He, Y Luo, D Zhang, X Wang… - American journal of …, 2019 - pmc.ncbi.nlm.nih.gov
Phosphoglycerate kinase 1 (PGK1) is an essential enzyme in the aerobic glycolysis
pathway. PGK1 catalyzes the reversible transfer of a phosphate group from 1, 3 …

Artificial intelligence for the otolaryngologist: a state of the art review

AM Bur, M Shew, J New - Otolaryngology–Head and Neck …, 2019 - journals.sagepub.com
Objective To provide a state of the art review of artificial intelligence (AI), including its
subfields of machine learning and natural language processing, as it applies to …

Artificial intelligence-assisted selection and efficacy prediction of antineoplastic strategies for precision cancer therapy

ZHE Zhang, X Wei - Seminars in Cancer Biology, 2023 - Elsevier
The rapid development of artificial intelligence (AI) technologies in the context of the vast
amount of collectable data obtained from high-throughput sequencing has led to an …

Artificial intelligence in salivary biomarker discovery and validation for oral diseases

J Adeoye, YX Su - Oral Diseases, 2024 - Wiley Online Library
Salivary biomarkers can improve the efficacy, efficiency, and timeliness of oral and
maxillofacial disease diagnosis and monitoring. Oral and maxillofacial conditions in which …

Quantitative protein biomarker panels: a path to improved clinical practice through proteomics

J Hartl, F Kurth, K Kappert, D Horst… - EMBO Molecular …, 2023 - embopress.org
The utilisation of protein biomarker panels, rather than individual protein biomarkers, offers a
more comprehensive representation of human physiology. It thus has the potential to …