Antigen presentation by major histocompatibility complex (MHC) proteins is essential for
adaptive immunity. Prior to presentation, peptides need to be generated from proteins that …

In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …

Human leukocyte antigen (HLA) class I allotypes vary in their ability to present peptides in
the absence of tapasin, an essential component of the peptide loading complex. We …

Immunological chaperones tapasin and TAP binding protein, related (TAPBPR) play key
roles in antigenic peptide optimization and quality control of nascent class I major …

Adaptive immunity depends on cell surface presentation of antigenic peptides by major
histocompatibility complex class I (MHC I) molecules and on stringent ER quality control in …

Peptides presented on MHC I molecules allow the immune system to detect diseased cells.
The displayed peptides typically stem from proteasomal degradation of cytoplasmic proteins …

Expressed on the surface of CD8+ T cells, the CD8 co-receptor is a key component of the T
cells that contributes to antigen recognition, immune cell maturation, and immune cell …

Chaperones TAPBPR and tapasin associate with class I major histocompatibility complexes
(MHC-I) to promote optimization (editing) of peptide cargo. Here, we use solution NMR to …

The repertoire of peptides presented by major histocompatibility complex class I (MHC-I)
molecules on the cell surface is tailored by the ER-resident peptide loading complex (PLC) …

Antigen presentation is a cellular process that involves a number of steps, beginning with
the production of peptides by proteolysis or aberrant synthesis and the delivery of peptides …