Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases
The fine balance between the secretion, composition, volume and turnover of cerebrospinal
fluid (CSF) is strictly regulated. However, during certain neurological diseases, this balance …
fluid (CSF) is strictly regulated. However, during certain neurological diseases, this balance …
The pathophysiology and treatment of delayed cerebral ischaemia following subarachnoid haemorrhage
Cerebral vasospasm has traditionally been regarded as an important cause of delayed
cerebral ischaemia (DCI) which occurs after aneurysmal subarachnoid haemorrhage, and …
cerebral ischaemia (DCI) which occurs after aneurysmal subarachnoid haemorrhage, and …
Haemoglobin scavenging in intracranial bleeding: biology and clinical implications
D Bulters, B Gaastra, A Zolnourian… - Nature Reviews …, 2018 - nature.com
Haemoglobin is released into the CNS during the breakdown of red blood cells after
intracranial bleeding. Extracellular free haemoglobin is directly neurotoxic. Haemoglobin …
intracranial bleeding. Extracellular free haemoglobin is directly neurotoxic. Haemoglobin …
Role of endothelial nitric oxide synthase for early brain injury after subarachnoid hemorrhage in mice
IJ Lenz, N Plesnila, NA Terpolilli - Journal of Cerebral Blood …, 2021 - journals.sagepub.com
The first few hours and days after subarachnoid hemorrhage (SAH) are characterized by
cerebral ischemia, spasms of pial arterioles, and a significant reduction of cerebral …
cerebral ischemia, spasms of pial arterioles, and a significant reduction of cerebral …
Are we barking up the wrong vessels? Cerebral microcirculation after subarachnoid hemorrhage
NA Terpolilli, C Brem, D Bühler, N Plesnila - Stroke, 2015 - Am Heart Assoc
The hypothesis that the cerebral microcirculation has to be involved in posthemorrhagic
cerebral ischemia was based on experimental studies showing that acutely following SAH …
cerebral ischemia was based on experimental studies showing that acutely following SAH …
Nitric oxide inhalation reduces brain damage, prevents mortality, and improves neurological outcome after subarachnoid hemorrhage by resolving early pial …
NA Terpolilli, S Feiler, A Dienel… - Journal of Cerebral …, 2016 - journals.sagepub.com
Subarachnoid hemorrhage is a stroke subtype with particularly bad outcome. Recent
findings suggest that constrictions of pial arterioles occurring early after hemorrhage may be …
findings suggest that constrictions of pial arterioles occurring early after hemorrhage may be …
Perivascular macrophages mediate microvasospasms after experimental subarachnoid hemorrhage
BACKGROUND: Subarachnoid hemorrhage (SAH) is characterized by acute and delayed
reductions of cerebral blood flow (CBF) caused, among others, by spasms of cerebral …
reductions of cerebral blood flow (CBF) caused, among others, by spasms of cerebral …
Scavenging free iron reduces arteriolar microvasospasms after experimental subarachnoid hemorrhage
H Liu, J Schwarting, NA Terpolilli, K Nehrkorn… - Stroke, 2021 - Am Heart Assoc
Background and Purpose: Subarachnoid hemorrhage (SAH) is associated with acute and
delayed cerebral ischemia resulting in high acute mortality and severe chronic neurological …
delayed cerebral ischemia resulting in high acute mortality and severe chronic neurological …
The acute phase of experimental subarachnoid hemorrhage: intracranial pressure dynamics and their effect on cerebral blood flow and autoregulation
C Conzen, K Becker, W Albanna, M Weiss… - Translational stroke …, 2019 - Springer
Clinical presentation and neurological outcome in subarachnoid hemorrhage (SAH) is
highly variable. Aneurysmal SAH (aSAH) is hallmarked by sudden increase of intracranial …
highly variable. Aneurysmal SAH (aSAH) is hallmarked by sudden increase of intracranial …
Intracisternal administration of tissue plasminogen activator improves cerebrospinal fluid flow and cortical perfusion after subarachnoid hemorrhage in mice
Early brain injury (EBI) during the first 72 h after subarachnoid hemorrhage (SAH) is an
important determinant of clinical outcome. A hallmark of EBI, global cerebral ischemia …
important determinant of clinical outcome. A hallmark of EBI, global cerebral ischemia …