Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases

SW Bothwell, D Janigro, A Patabendige - Fluids and Barriers of the CNS, 2019 - Springer
The fine balance between the secretion, composition, volume and turnover of cerebrospinal
fluid (CSF) is strictly regulated. However, during certain neurological diseases, this balance …

The pathophysiology and treatment of delayed cerebral ischaemia following subarachnoid haemorrhage

KP Budohoski, M Guilfoyle, A Helmy… - Journal of Neurology …, 2014 - jnnp.bmj.com
Cerebral vasospasm has traditionally been regarded as an important cause of delayed
cerebral ischaemia (DCI) which occurs after aneurysmal subarachnoid haemorrhage, and …

Haemoglobin scavenging in intracranial bleeding: biology and clinical implications

D Bulters, B Gaastra, A Zolnourian… - Nature Reviews …, 2018 - nature.com
Haemoglobin is released into the CNS during the breakdown of red blood cells after
intracranial bleeding. Extracellular free haemoglobin is directly neurotoxic. Haemoglobin …

Role of endothelial nitric oxide synthase for early brain injury after subarachnoid hemorrhage in mice

IJ Lenz, N Plesnila, NA Terpolilli - Journal of Cerebral Blood …, 2021 - journals.sagepub.com
The first few hours and days after subarachnoid hemorrhage (SAH) are characterized by
cerebral ischemia, spasms of pial arterioles, and a significant reduction of cerebral …

Are we barking up the wrong vessels? Cerebral microcirculation after subarachnoid hemorrhage

NA Terpolilli, C Brem, D Bühler, N Plesnila - Stroke, 2015 - Am Heart Assoc
The hypothesis that the cerebral microcirculation has to be involved in posthemorrhagic
cerebral ischemia was based on experimental studies showing that acutely following SAH …

Nitric oxide inhalation reduces brain damage, prevents mortality, and improves neurological outcome after subarachnoid hemorrhage by resolving early pial …

NA Terpolilli, S Feiler, A Dienel… - Journal of Cerebral …, 2016 - journals.sagepub.com
Subarachnoid hemorrhage is a stroke subtype with particularly bad outcome. Recent
findings suggest that constrictions of pial arterioles occurring early after hemorrhage may be …

Perivascular macrophages mediate microvasospasms after experimental subarachnoid hemorrhage

X Lin, I Khalin, BN Harapan, NA Terpolilli, J Schwarting… - Stroke, 2023 - Am Heart Assoc
BACKGROUND: Subarachnoid hemorrhage (SAH) is characterized by acute and delayed
reductions of cerebral blood flow (CBF) caused, among others, by spasms of cerebral …

Scavenging free iron reduces arteriolar microvasospasms after experimental subarachnoid hemorrhage

H Liu, J Schwarting, NA Terpolilli, K Nehrkorn… - Stroke, 2021 - Am Heart Assoc
Background and Purpose: Subarachnoid hemorrhage (SAH) is associated with acute and
delayed cerebral ischemia resulting in high acute mortality and severe chronic neurological …

The acute phase of experimental subarachnoid hemorrhage: intracranial pressure dynamics and their effect on cerebral blood flow and autoregulation

C Conzen, K Becker, W Albanna, M Weiss… - Translational stroke …, 2019 - Springer
Clinical presentation and neurological outcome in subarachnoid hemorrhage (SAH) is
highly variable. Aneurysmal SAH (aSAH) is hallmarked by sudden increase of intracranial …

Intracisternal administration of tissue plasminogen activator improves cerebrospinal fluid flow and cortical perfusion after subarachnoid hemorrhage in mice

DA Siler, JA Gonzalez, RK Wang, JS Cetas… - Translational stroke …, 2014 - Springer
Early brain injury (EBI) during the first 72 h after subarachnoid hemorrhage (SAH) is an
important determinant of clinical outcome. A hallmark of EBI, global cerebral ischemia …