Proteases form one of the largest and more important groups of enzymes. They selectively
catalyze the hydrolysis of peptide bonds and can be divided into four major classes …

The ubiquitin‐proteasome pathway has emerged as a central player in the regulation of
several diverse cellular processes. Here, we describe the important components of this …

Amyloid-β proteins (Aβ) of 42 (Aβ42) and 40 aa (Aβ40) accumulate as senile plaques (SP)
and cerebrovascular amyloid protein deposits that are defining diagnostic features of …

The gut microbiota coevolves with its host, and numerous factors like diet, lifestyle, drug
intake and geographical location continuously modify its composition, deeply influencing …

Postmortem analysis of brains of patients with Alzheimer's disease (AD) has led to diverse
theories about the causes of the pathology, suggesting that this complex disease involves …

The 26S proteasome constitutes the central proteolytic machinery of the highly conserved
ubiquitin/proteasome system, the cell's major tool for extralysosomal protein degradation …

• Introduction• Biology of the UPS‐The tagging reaction‐Structure of the proteasome• The
involvement of the UPS in AD pathogenesis‐The interaction between Aβ and the …

In this study, we investigated the presence and role of immunoproteasome and its LMP2
subunit polymorphism at codon 60 in Alzheimer's disease (AD). Immunoproteasome was …

Various physiological, biochemical and molecular biological disturbances have been put
forward as mediators of neuronal cell injury in acute and chronic pathological states of the …

Previous studies have suggested a possible relationship between the ubiquitin–proteasome
pathway and some pathological manifestations of Alzheimer's disease (AD). This study …