Perivascular adipose tissue (PVAT) releases several important vasoactive factors with
physiological and pathophysiological paracrine effects. A large body of evidence suggests …

Obesity is a well-established risk factor for atherosclerosis. However, the mechanistic link
between accumulation of adipose tissue and development of atherosclerosis is not clear …

Adipose tissue is a heterogeneous organ with remarkable variations in fat cell metabolism
depending on the anatomical location. However, the pattern and distribution of bioactive …

Since the “rediscovery” of brown adipose tissue in adult humans, significant scientific efforts
are being pursued to identify the molecular mechanisms to promote a phenotypic change of …

Adipose tissue has recently been reevaluated as an endocrine organ, and adipose‐tissue‐
derived endocrine factors are termed adipokines. Plasminogen activator inhibitor‐1 (PAI‐1) …

Among lean populations, cardiovascular disease (CVD) is rare. Among those with increased
adiposity, CVD is the commonest cause of worldwide death. The “obesity paradox” …

Perivascular adipose tissue (PVAT) is now recognized as an active player in vascular
homeostasis. The expansion of PVAT in obesity and its possible role in vascular dysfunction …

Perivascular adipose tissue (PVAT) is cushion of fat tissue surrounding blood vessels, which
is phenotypically different from other adipose tissue depots. PVAT is composed of …

Background: Accumulating evidence demonstrates that perivascular adipose tissue (PVAT)
plays an important role in maintaining vascular homeostasis. The formation of macrophage …

Chronic low-grade inflammation in adipose tissue has been recognized as a key step in the
development of obesity-associated complications. In obesity, the accumulation of infiltrating …