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Epithelial barriers in allergy and asthma
The respiratory epithelium provides a physical, functional, and immunologic barrier to
protect the host from the potential harming effects of inhaled environmental particles and to …
protect the host from the potential harming effects of inhaled environmental particles and to …
[HTML][HTML] Genetics and epigenetics in asthma
Asthma is one of the most common respiratory disease that affects both children and adults
worldwide, with diverse phenotypes and underlying pathogenetic mechanisms poorly …
worldwide, with diverse phenotypes and underlying pathogenetic mechanisms poorly …
Cellular and molecular mechanisms of allergic asthma
Asthma is a chronic disease of the airways, which affects more than 350 million people
worldwide. It is the most common chronic disease in children, affecting at least 30 million …
worldwide. It is the most common chronic disease in children, affecting at least 30 million …
Epithelial cell dysfunction, a major driver of asthma development
Airway epithelial barrier dysfunction is frequently observed in asthma and may have
important implications. The physical barrier function of the airway epithelium is tightly …
important implications. The physical barrier function of the airway epithelium is tightly …
[HTML][HTML] Airway remodelling in asthma and the epithelium: on the edge of a new era
Asthma is a chronic, heterogeneous disease of the airways, often characterised by structural
changes known collectively as airway remodelling. In response to environmental insults …
changes known collectively as airway remodelling. In response to environmental insults …
More than just a barrier: the immune functions of the airway epithelium in asthma pathogenesis
Allergic bronchial asthma is a chronic disease of the airways that is characterized by
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …
Role of viruses in asthma
Respiratory viral infections are the most important triggers of asthma exacerbations.
Rhinovirus (RV), the common cold virus, is clearly the most prevalent pathogen constantly …
Rhinovirus (RV), the common cold virus, is clearly the most prevalent pathogen constantly …
The nasal methylome as a biomarker of asthma and airway inflammation in children
The nasal cellular epigenome may serve as biomarker of airway disease and environmental
response. Here we collect nasal swabs from the anterior nares of 547 children (mean-age …
response. Here we collect nasal swabs from the anterior nares of 547 children (mean-age …
Immunological resilience and biodiversity for prevention of allergic diseases and asthma
Increase of allergic conditions has occurred at the same pace with the Great Acceleration,
which stands for the rapid growth rate of human activities upon earth from 1950s. Changes …
which stands for the rapid growth rate of human activities upon earth from 1950s. Changes …
Epigenome-wide association analysis of infant bronchiolitis severity: a multicenter prospective cohort study
Bronchiolitis is the most common lower respiratory infection in infants, yet its pathobiology
remains unclear. Here we present blood DNA methylation data from 625 infants hospitalized …
remains unclear. Here we present blood DNA methylation data from 625 infants hospitalized …