ROS: Basic concepts, sources, cellular signaling, and its implications in aging pathways

AJPO de Almeida, JCPL de Oliveira… - Oxidative medicine …, 2022 - Wiley Online Library
Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …

Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation

SX Gu, T Tyagi, K Jain, VW Gu, SH Lee… - Nature Reviews …, 2021 - nature.com
The core pathology of coronavirus disease 2019 (COVID-19) is infection of airway cells by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …

Hypertension-induced cognitive impairment: from pathophysiology to public health

Z Ungvari, P Toth, S Tarantini, CI Prodan… - Nature Reviews …, 2021 - nature.com
Hypertension affects two-thirds of people aged> 60 years and significantly increases the risk
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …

The multifaceted benefits of walking for healthy aging: from Blue Zones to molecular mechanisms

Z Ungvari, V Fazekas-Pongor, A Csiszar, SK Kunutsor - Geroscience, 2023 - Springer
Physical activity, including walking, has numerous health benefits in older adults, supported
by a plethora of observational and interventional studies. Walking decreases the risk or …

[HTML][HTML] COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches

F Moccia, A Gerbino, V Lionetti, M Miragoli… - Geroscience, 2020 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells following
binding with the cell surface ACE2 receptors, thereby leading to coronavirus disease 2019 …

Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures

T Pandics, D Major, V Fazekas-Pongor, Z Szarvas… - Geroscience, 2023 - Springer
The aging population worldwide is facing a significant increase in age-related non-
communicable diseases, including cardiovascular and brain pathologies. This …

New dawn for atherosclerosis: vascular endothelial cell senescence and death

LL Bu, HH Yuan, LL **e, MH Guo, DF Liao… - International journal of …, 2023 - mdpi.com
Endothelial cells (ECs) form the inner linings of blood vessels, and are directly exposed to
endogenous hazard signals and metabolites in the circulatory system. The senescence and …

Endothelial Dysfunction, Inflammation, and Oxidative Stress in COVID‐19—Mechanisms and Therapeutic Targets

A Fodor, B Tiperciuc, C Login… - Oxidative medicine …, 2021 - Wiley Online Library
The outbreak of the COVID‐19 pandemic represents an ongoing healthcare emergency
responsible for more than 3.4 million deaths worldwide. COVID‐19 is the disease caused by …

[HTML][HTML] Polychemotherapy with curcumin and doxorubicin via biological nanoplatforms: enhancing antitumor activity

M Ashrafizadeh, A Zarrabi, F Hashemi, A Zabolian… - Pharmaceutics, 2020 - mdpi.com
Doxorubicin (DOX) is a well-known chemotherapeutic agent extensively applied in the field
of cancer therapy. However, similar to other chemotherapeutic agents such as cisplatin …

[PDF][PDF] Geroscience and pathology: a new frontier in understanding age-related diseases

M Fekete, D Major, A Feher… - Pathology and …, 2024 - por-journal.com
Geroscience, an emerging discipline at the intersection of aging and disease, seeks to
understand the relationship between the aging process and pathogenesis of age-related …