Pathological angiogenesis: mechanisms and therapeutic strategies
In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …
existing ones, is an essential process for growth and development. Different mechanisms …
Long noncoding RNA (lncRNA)-mediated competing endogenous RNA networks provide novel potential biomarkers and therapeutic targets for colorectal cancer
Colorectal cancer (CRC) is the third most common cancer and has a high metastasis and
reoccurrence rate. Long noncoding RNAs (lncRNAs) play an important role in CRC growth …
reoccurrence rate. Long noncoding RNAs (lncRNAs) play an important role in CRC growth …
[HTML][HTML] Machine learning identifies stemness features associated with oncogenic dedifferentiation
Cancer progression involves the gradual loss of a differentiated phenotype and acquisition
of progenitor and stem-cell-like features. Here, we provide novel stemness indices for …
of progenitor and stem-cell-like features. Here, we provide novel stemness indices for …
Recovering gene interactions from single-cell data using data diffusion
Single-cell RNA sequencing technologies suffer from many sources of technical noise,
including under-sampling of mRNA molecules, often termed" dropout," which can severely …
including under-sampling of mRNA molecules, often termed" dropout," which can severely …
The FUS/circEZH2/KLF5/feedback loop contributes to CXCR4-induced liver metastasis of breast cancer by enhancing epithelial-mesenchymal transition
P Liu, Z Wang, X Ou, P Wu, Y Zhang, S Wu, X **ao… - Molecular cancer, 2022 - Springer
Background Metastasis of breast cancer have caused the majority of cancer-related death
worldwide. The circRNAs are associated with tumorigenesis and metastasis in breast cancer …
worldwide. The circRNAs are associated with tumorigenesis and metastasis in breast cancer …
Chemoresistance evolution in triple-negative breast cancer delineated by single-cell sequencing
Triple-negative breast cancer (TNBC) is an aggressive subtype that frequently develops
resistance to chemotherapy. An unresolved question is whether resistance is caused by the …
resistance to chemotherapy. An unresolved question is whether resistance is caused by the …
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
A Singh, J Settleman - Oncogene, 2010 - nature.com
Tumors are cellularly and molecularly heterogeneous, with subsets of undifferentiated
cancer cells exhibiting stem cell-like features (CSCs). Epithelial to mesenchymal transitions …
cancer cells exhibiting stem cell-like features (CSCs). Epithelial to mesenchymal transitions …
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA
N 6-methyladenosine (m6A) modification of mRNA plays a role in regulating embryonic stem
cell pluripotency. However, the physiological signals that determine the balance between …
cell pluripotency. However, the physiological signals that determine the balance between …
The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer
R Cunningham, CG Hansen - Clinical Science, 2022 - portlandpress.com
Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …
signalling pathways. One such pathway that has garnered much attention in the field of …
[HTML][HTML] Stem cell programs in cancer initiation, progression, and therapy resistance
Over the past few decades, substantial evidence has convincingly revealed the existence of
cancer stem cells (CSCs) as a minor subpopulation in cancers, contributing to an aberrantly …
cancer stem cells (CSCs) as a minor subpopulation in cancers, contributing to an aberrantly …