Immunosenescence and its hallmarks: how to oppose aging strategically? A review of potential options for therapeutic intervention
A Aiello, F Farzaneh, G Candore, C Caruso… - Frontiers in …, 2019 - frontiersin.org
Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …
The science and medicine of human immunology
B Pulendran, MM Davis - Science, 2020 - science.org
BACKGROUND The mammalian immune system is a remarkable sensory system for the
detection and neutralization of pathogens. History is replete with the devastating effects of …
detection and neutralization of pathogens. History is replete with the devastating effects of …
Of mice and not men: differences between mouse and human immunology
J Mestas, CCW Hughes - The Journal of Immunology, 2004 - journals.aai.org
Mice are the experimental tool of choice for the majority of immunologists and the study of
their immune responses has yielded tremendous insight into the workings of the human …
their immune responses has yielded tremendous insight into the workings of the human …
IL-7: comprehensive review
Overview IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind
Type I cytokine receptors. It is produced by stromal cells and is required for development …
Type I cytokine receptors. It is produced by stromal cells and is required for development …
Practice parameter for the diagnosis and management of primary immunodeficiency
FA Bonilla, DA Khan, ZK Ballas, J Chinen… - Journal of Allergy and …, 2015 - Elsevier
The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …
Biology of hematopoietic stem cells and progenitors: implications for clinical application
M Kondo, AJ Wagers, MG Manz… - Annual review of …, 2003 - annualreviews.org
▪ Abstract Stem cell biology is scientifically, clinically, and politically a current topic. The
hematopoietic stem cell, the common ancestor of all types of blood cells, is one of the best …
hematopoietic stem cell, the common ancestor of all types of blood cells, is one of the best …
Bone marrow and the control of immunity
E Zhao, H Xu, L Wang, I Kryczek, K Wu, Y Hu… - Cellular & molecular …, 2012 - nature.com
Bone marrow is thought to be a primary hematopoietic organ. However, accumulated
evidences demonstrate that active function and trafficking of immune cells, including …
evidences demonstrate that active function and trafficking of immune cells, including …
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia
PP Zenatti, D Ribeiro, W Li, L Zuurbier, MC Silva… - Nature …, 2011 - nature.com
Abstract Interleukin 7 (IL-7) and its receptor, formed by IL-7Rα (encoded by IL7R) and γc, are
essential for normal T-cell development and homeostasis. Here we show that IL7R is an …
essential for normal T-cell development and homeostasis. Here we show that IL7R is an …
Цитокины в патогенезе и лечении заболеваний человека
АС Симбирцев - 2018 - elibrary.ru
В монографии приведены сведения по роли цитокинов в регуляции физиологических
процессов, защитных реакций организма и в патогенезе иммунопатологических …
процессов, защитных реакций организма и в патогенезе иммунопатологических …
Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution
RH Buckley - Annu. Rev. Immunol., 2004 - annualreviews.org
▪ Abstract Mutations in nine different genes have been found to cause the human severe
combined immunodeficiency syndrome. The products of three of the genes—IL-2RG, Jak3 …
combined immunodeficiency syndrome. The products of three of the genes—IL-2RG, Jak3 …