Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects

M Li, Y Jiang, Q Hou, Y Zhao, L Zhong, X Fu - Stem cell research & …, 2022 - Springer
Mesenchymal stem cell (MSC)-based therapy has been considered as a promising
approach targeting a variety of intractable diseases due to remarkable multiple effect of …

Current therapeutic strategies in diabetic foot ulcers

A Perez-Favila, ML Martinez-Fierro… - Medicina, 2019 - mdpi.com
Diabetic foot ulcers (DFUs) are the fastest growing chronic complication of diabetes mellitus,
with more than 400 million people diagnosed globally, and the condition is responsible for …

Melatonin enhances osteogenic differentiation of dental pulp mesenchymal stem cells by regulating MAPK pathways and promotes the efficiency of bone regeneration …

YH Chan, KN Ho, YC Lee, MJ Chou, WZ Lew… - Stem Cell Research & …, 2022 - Springer
Background Mesenchymal stem cell (MSC)-based tissue engineering plays a major role in
regenerative medicine. However, the efficiency of MSC transplantation and survival of …

Challenges and strategies for improving the regenerative effects of mesenchymal stromal cell-based therapies

S Baldari, G Di Rocco, M Piccoli, M Pozzobon… - International journal of …, 2017 - mdpi.com
Cell-based therapies have the potential to revolutionize current treatments for diseases with
high prevalence and related economic and social burden. Unfortunately, clinical trials have …

HIF-1α regulates bone homeostasis and angiogenesis, participating in the occurrence of bone metabolic diseases

W Chen, P Wu, F Yu, G Luo, L Qing, J Tang - Cells, 2022 - mdpi.com
In the physiological condition, the skeletal system's bone resorption and formation are in
dynamic balance, called bone homeostasis. However, bone homeostasis is destroyed under …

[HTML][HTML] Translational insights into stem cell preconditioning: from molecular mechanisms to preclinical applications

K Moeinabadi-Bidgoli, A Babajani… - Biomedicine & …, 2021 - Elsevier
Cell-based therapy (CBT) is a revolutionary approach for curing a variety of degenerative
diseases. Stem cell-based regenerative medicine is a novel strategy for treating tissue …

Human adipose-derived mesenchymal stem cell-conditioned medium ameliorates polyneuropathy and foot ulceration in diabetic BKS db/db mice

C De Gregorio, D Contador, D Díaz, C Cárcamo… - Stem Cell Research & …, 2020 - Springer
Background Diabetic polyneuropathy (DPN) is the most common and early develo**
complication of diabetes mellitus, and the key contributor for foot ulcers development, with …

Current status of the applications of conditioned media derived from mesenchymal stem cells for regenerative medicine

V Smolinska, M Boháč… - Physiological research, 2023 - pmc.ncbi.nlm.nih.gov
Recently published studies suggest that the paracrine substances released by
mesenchymal stem cells (MSCs) are the primary motive behind the therapeutic action …

Deferoxamine: an angiogenic and antioxidant molecule for tissue regeneration

P Holden, LS Nair - Tissue Engineering Part B: Reviews, 2019 - liebertpub.com
Deferoxamine (DFO) has been in use for half a century as a Food and Drug Administration-
approved iron chelator, but recent studies indicate a variety of properties that could expand …

The crosstalk of adipose-derived stem cells (ADSC), oxidative stress, and inflammation in protective and adaptive responses

L Rochette, L Mazini, G Malka, M Zeller… - International journal of …, 2020 - mdpi.com
The potential use of stem cell-based therapies for the repair and regeneration of various
tissues and organs is a major goal in repair medicine. Stem cells are classified by their …