Lactate in the regulation of tumor microenvironment and therapeutic approaches

KG de la Cruz-López, LJ Castro-Muñoz… - Frontiers in …, 2019 - frontiersin.org
Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain
cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts …

Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection

P Fuentes-Prior - Journal of Biological Chemistry, 2021 - ASBMB
The ongoing COVID-19 pandemic has already caused over a million deaths worldwide, and
this death toll will be much higher before effective treatments and vaccines are available …

Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions

D Butler, C Mozsary, C Meydan, J Foox… - Nature …, 2021 - nature.com
In less than nine months, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV-2) killed over a million people, including> 25,000 in New York City (NYC) alone. The …

Hyperpolarized MRI of human prostate cancer reveals increased lactate with tumor grade driven by monocarboxylate transporter 1

KL Granlund, SS Tee, HA Vargas, SK Lyashchenko… - Cell metabolism, 2020 - cell.com
Metabolic imaging using hyperpolarized magnetic resonance can increase the sensitivity of
MRI, though its ability to inform on relevant changes to biochemistry in humans remains …

[HTML][HTML] Shotgun transcriptome and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions

DJ Butler, C Mozsary, C Meydan, D Danko, J Foox… - BioRxiv, 2020 - ncbi.nlm.nih.gov
Abstract The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused
thousands of deaths worldwide, including> 18,000 in New York City (NYC) alone. The …

Role of proton-coupled monocarboxylate transporters in cancer: from metabolic crosstalk to therapeutic potential

X Sun, M Wang, M Wang, L Yao, X Li… - Frontiers in cell and …, 2020 - frontiersin.org
Proton-coupled monocarboxylate transporters (MCTs), representing the first four isoforms of
the SLC16A gene family, mainly participate in the transport of lactate, pyruvate, and other …

[HTML][HTML] Metabolic reprogramming in tumors: Contributions of the tumor microenvironment

AN Lane, RM Higashi, TWM Fan - Genes & diseases, 2020 - Elsevier
The genetic alterations associated with cell transformation are in large measure expressed
in the metabolic phenotype as cancer cells proliferate and change their local environment …

Glucose metabolism and tumour microenvironment in pancreatic cancer: A key link in cancer progression

S Dong, W Li, X Li, Z Wang, Z Chen, H Shi… - Frontiers in …, 2022 - frontiersin.org
Early and accurate diagnosis and treatment of pancreatic cancer (PC) remain challenging
endeavors globally. Late diagnosis lag, high invasiveness, chemical resistance, and poor …

Di-methylation of CD147-K234 promotes the progression of NSCLC by enhancing lactate export

K Wang, W Huang, R Chen, P Lin, T Zhang, YF Ni, H Li… - Cell Metabolism, 2021 - cell.com
CD147 is a tumor-associated glycoprotein that regulates cell metabolism. However, CD147
methylation and its subsequent role in cancer cell metabolism remain unclear. Here, we …

Understanding the contribution of lactate metabolism in cancer progress: a perspective from isomers

M Cai, J Wan, K Cai, H Song, Y Wang, W Sun, J Hu - Cancers, 2022 - mdpi.com
Simple Summary Lactate (L-lactate and D-lactate) is the main production of the Warburg
effect, which is vital for carcinoma cell metabolism. This review retrospects the lactate isomer …