Gene–stress–epigenetic regulation of FKBP5: clinical and translational implications
Stress responses and related outcomes vary markedly across individuals. Elucidating the
molecular underpinnings of this variability is of great relevance for develo** individualized …
molecular underpinnings of this variability is of great relevance for develo** individualized …
Environmental risk factors for schizophrenia and bipolar disorder and their relationship to genetic risk: current knowledge and future directions
N Robinson, SE Bergen - Frontiers in genetics, 2021 - frontiersin.org
Schizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric disorders which result
from complex interplay between genetic and environmental factors. It is well-established that …
from complex interplay between genetic and environmental factors. It is well-established that …
Gene–environment interactions in severe mental illness
R Uher - Frontiers in psychiatry, 2014 - frontiersin.org
Severe mental illness (SMI) is a broad category that includes schizophrenia, bipolar
disorder, and severe depression. Both genetic disposition and environmental exposures …
disorder, and severe depression. Both genetic disposition and environmental exposures …
Childhood adversities and psychosis: evidence, challenges, implications
C Morgan, C Gayer‐Anderson - World psychiatry, 2016 - Wiley Online Library
There is a substantial body of research reporting evidence of associations between various
forms of childhood adversity and psychosis, across the spectrum from experiences to …
forms of childhood adversity and psychosis, across the spectrum from experiences to …
The effects of early life stress on the epigenome: from the womb to adulthood and even before
N Provençal, EB Binder - Experimental neurology, 2015 - Elsevier
Exposure to early life stress (ELS), such as childhood abuse and neglect is a well
established major risk factor for develo** psychiatric and behavioral disorders later in life …
established major risk factor for develo** psychiatric and behavioral disorders later in life …
Understanding the molecular mechanisms underpinning gene by environment interactions in psychiatric disorders: the FKBP5 model
Epidemiologic and genetic studies suggest common environmental and genetic risk factors
for a number of psychiatric disorders, including depression, bipolar disorder, and …
for a number of psychiatric disorders, including depression, bipolar disorder, and …
Neurobiological development in the context of childhood trauma.
Neurobiological systems may be particularly susceptible to the deleterious impact of
childhood trauma, and the impact of childhood trauma on development and subsequent …
childhood trauma, and the impact of childhood trauma on development and subsequent …
Gene–environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism
Psychiatric phenotypes are multifactorial and polygenic, resulting from the complex interplay
of genes and environmental factors that act cumulatively throughout an organism's lifetime …
of genes and environmental factors that act cumulatively throughout an organism's lifetime …
Interactions between variation in candidate genes and environmental factors in the etiology of schizophrenia and bipolar disorder: a systematic review
Schizophrenia and bipolar disorder (BD) are complex and multidimensional disorders with
high heritability rates. The contribution of genetic factors to the etiology of these disorders is …
high heritability rates. The contribution of genetic factors to the etiology of these disorders is …
Trauma and the psychosis spectrum: A review of symptom specificity and explanatory mechanisms
Traumatic life events have been robustly associated with various psychosis outcomes,
including increased risk of psychotic disorders, the prodrome of psychosis, and dimensional …
including increased risk of psychotic disorders, the prodrome of psychosis, and dimensional …