Nature achieves differentiation of specific and nonspecific binding in molecular interactions
through precise control of biomolecules in space and time. Artificial systems such as …

During the last three decades, a series of key technological improvements turned atomic
force microscopy (AFM) into a nanoscopic laboratory to directly observe and chemically …

Single-cell profiling methods have had a profound impact on the understanding of cellular
heterogeneity. While genomes and transcriptomes can be explored at the single-cell level …

Single entity sensing is recently an area of tremendous interest in analytical chemistry, such
that it is possible to analyze single cells, single particles, and even single molecules. Among …

We report artificial nanopores in the form of quartz nanopipettes with ca. 10 nm orifices
functionalized with molecular recognition elements termed aptamers that reversibly …

Scanning ion conductance microscopy (SICM) has emerged as a versatile tool for studies of
interfaces in biology and materials science with notable utility in biophysical and …

Fluidic force microscopy (FluidFM), which combines atomic force microscopy (AFM) with
microchanneled cantilevers connected to a pressure controller, is a technique allowing the …

Detection of cancer markers is important for early diagnosis and timely treatment of cancer.
In this study, we fabricated a tailorable gold nanofilm-anodized aluminum oxide (Au-AAO) …

In current nanopore-based label-free single-molecule sensing technologies, stochastic
processes influence the selection of translocating molecule, translocation rate and …

Nanorobotics, which has long been a fantasy in the realm of science fiction, is now a reality
due to the considerable developments in diverse fields including chemistry, materials …