Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges

DA Starr, HN Fridolfsson - Annual review of cell and …, 2010 - annualreviews.org
The nuclear envelope links the cytoskeleton to structural components of the nucleus. It
functions to coordinate nuclear migration and anchorage, organize chromatin, and aid …

Life at the crossroads: the nuclear LINC complex and vascular mechanotransduction

P Bougaran, VL Bautch - Frontiers in physiology, 2024 - frontiersin.org
Vascular endothelial cells line the inner surface of all blood vessels, where they are
exposed to polarized mechanical forces throughout their lifespan. Both basal substrate …

LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins

BA Sosa, A Rothballer, U Kutay, TU Schwartz - Cell, 2012 - cell.com
Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the nuclear envelope
and are composed of KASH and SUN proteins residing in the outer and inner nuclear …

Connecting the nucleus to the cytoskeleton by SUN–KASH bridges across the nuclear envelope

EC Tapley, DA Starr - Current opinion in cell biology, 2013 - Elsevier
The nuclear–cytoskeleton connection influences many aspects of cellular architecture,
including nuclear positioning, the stiffness of the global cytoskeleton, and …

Building and breaking mechanical bridges between the nucleus and cytoskeleton: Regulation of LINC complex assembly and disassembly

RM McGillivary, DA Starr, GWG Luxton - Current opinion in cell biology, 2023 - Elsevier
The nucleus is physically coupled to the cytoskeleton through LINC complexes,
macromolecular bridges composed of SUN and KASH proteins that span the nuclear …

The SUN rises on meiotic chromosome dynamics

Y Hiraoka, AF Dernburg - Developmental cell, 2009 - cell.com
Recent studies in diverse eukaryotes have implicated a family of nuclear envelope proteins
containing SUN domains as key components of meiotic nuclear organization and …

In vitro cytotoxicity effects of zinc oxide nanoparticles on spermatogonia cells

AR Pinho, F Martins, MEV Costa, AMR Senos… - Cells, 2020 - mdpi.com
Zinc Oxide Nanoparticles (ZnO NPs) are a type of metal oxide nanoparticle with an
extensive use in biomedicine. Several studies have focused on the biosafety of ZnO NPs …

Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins

C Ostlund, ES Folker, JC Choi… - Journal of cell …, 2009 - journals.biologists.com
The linker of nucleoskeleton and cytoskeleton (LINC) complex is situated in the nuclear
envelope and forms a connection between the lamina and cytoskeletal elements. Sun1 …

A nuclear-envelope bridge positions nuclei and moves chromosomes

DA Starr - Journal of cell science, 2009 - journals.biologists.com
Positioning the nucleus is essential for the formation of polarized cells, pronuclear migration,
cell division, cell migration and the organization of specialized syncytia such as mammalian …

Centrifugal displacement of nuclei reveals multiple LINC complex mechanisms for homeostatic nuclear positioning

R Zhu, S Antoku, GG Gundersen - Current Biology, 2017 - cell.com
Nuclear movement is critical for developmental events, cell polarity, and migration and is
usually mediated by linker of nucleoskeleton and cytoskeleton (LINC) complexes connecting …