Human cancers share properties referred to as hallmarks, among which sustained
proliferation, escape from apoptosis, and genomic instability are the most pervasive. The …

At each cell division in humans, 30,000–50,000 DNA replication origins are activated, and it
remains unclear how they are selected and recognized by replication factors. DNA …

Background Co-transcriptional R-loops are abundant non-B DNA structures in mammalian
genomes. DNA Topoisomerase I (Top1) is often thought to regulate R-loop formation owing …

Mechanisms regulating where and when eukaryotic DNA replication initiates remain a
mystery. Recently, genome-scale methods have been brought to bear on this problem. The …

The duplication of mammalian genomes is under the control of a spatiotemporal program
that orchestrates the positioning and the timing of firing of replication origins. The molecular …

Understanding how chromatin is spatially and dynamically organized in the nucleus of
eukaryotic cells and how this affects genome functions is one of the main challenges of cell …

The MYC oncogene is a multifunctional protein that is aberrantly expressed in a significant
fraction of tumors from diverse tissue origins. Because of its multifunctional nature, it has …

The discovery of the DNA double helix structure half a century ago immediately suggested a
mechanism for its duplication by semi-conservative copying of the nucleotide sequence into …

During evolution, mutations occur at rates that can differ between the two DNA strands. In
the human genome, nucleotide substitutions occur at different rates on the transcribed and …

Replication and transcription are key aspects of DNA metabolism that take place on the
same template and potentially interfere with each other. Conflicts between these two …