Ketone bodies: from enemy to friend and guardian angel

H Kolb, K Kempf, M Röhling, M Lenzen-Schulte… - BMC medicine, 2021 - Springer
During starvation, fasting, or a diet containing little digestible carbohydrates, the circulating
insulin levels are decreased. This promotes lipolysis, and the breakdown of fat becomes the …

Tea tree oil, a vibrant source of neuroprotection via neuroinflammation inhibition: a critical insight into repurposing Melaleuca alternifolia by unfolding its …

MA Rahman, A Sultana, MF Khan, R Boonhok… - Journal of Zhejiang …, 2023 - Springer
Over the past few decades, complementary and alternative treatments have become
increasingly popular worldwide. The purported therapeutic characteristics of natural …

[HTML][HTML] High concentrations of fatty acids and β-hydroxybutyrate impair the growth hormone-mediated hepatic JAK2-STAT5 pathway in clinically ketotic cows

X Du, Y Zhu, Z Peng, Y Cui, Q Zhang, Z Shi… - Journal of Dairy …, 2018 - Elsevier
The hepatic growth hormone (GH)–insulin-like growth factor (IGF)-I axis is essential for
regulating intrahepatic lipid metabolism. Ketotic cows are characterized by high blood …

[HTML][HTML] Transcriptomic and metabolomic insights into the roles of exogenous β-hydroxybutyrate acid for the development of rumen epithelium in young goats

Y Zhuang, J Chai, MM Abdelsattar, Y Fu, N Zhang - Animal Nutrition, 2023 - Elsevier
Abstract Beta-hydroxybutyric acid (BHBA), as one of the main metabolic ketones in the
rumen epithelium, plays critical roles in cellular growth and metabolism. The ketogenic …

[HTML][HTML] Hepatic nuclear factor kappa B signaling pathway and NLR family pyrin domain containing 3 inflammasome is over-activated in ketotic dairy cows

T Shen, X Li, JJ Loor, Y Zhu, X Du, X Wang, D **ng… - Journal of dairy …, 2019 - Elsevier
Ketosis is an important metabolic disease that can negatively affect the production efficiency
of dairy cows. Earlier studies have revealed metabolic and inflammatory alterations in the …

[HTML][HTML] Acetic acid influences BRL-3A cell lipid metabolism via the AMPK signalling pathway

L Li, M He, H **ao, X Liu, K Wang… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Acetic acid (AcOH), a short-chain fatty acid, is reported to have some
beneficial effects on metabolism. Therefore, the aim of this study was to investigate the …

[HTML][HTML] Hepatic autophagy and mitophagy status in dairy cows with subclinical and clinical ketosis

T Shen, F Xu, Z Fang, JJ Loor, H Ouyang, M Chen… - Journal of Dairy …, 2021 - Elsevier
Severe negative energy balance around parturition is an important contributor to ketosis, a
metabolic disorder that occurs most frequently in the peripartal period. Autophagy and …

Choline and methionine regulate lipid metabolism via the AMPK signaling pathway in hepatocytes exposed to high concentrations of nonesterified fatty acids

J Shen, B Sun, C Yu, Y Cao, C Cai… - Journal of Cellular …, 2020 - Wiley Online Library
High concentrations of nonesterified fatty acids (NEFAs) and β‐hydroxybutyric acid (BHBA)
induce lipid peroxidation, resulting in liver damage. Choline and methionine (Met) can …

[HTML][HTML] Liver transcriptome analysis reveals important factors involved in the metabolic adaptation of the transition cow

NT Ha, C Drögemüller, C Reimer, F Schmitz-Hsu… - Journal of dairy …, 2017 - Elsevier
During early lactation, dairy cows experience a severe metabolic load often resulting in the
development of various diseases. The inevitable deficiency in nutrients and energy at the …

The role of tea tree oil in alleviating palmitic acid-induced lipid accumulation in bovine hepatocytes

T Yang, X Ma, M Jiang, Z Cheng… - Frontiers in Veterinary …, 2022 - frontiersin.org
Tea tree oil (TTO) plays an important role in lipid metabolism, alleviating the inflammatory
responses. Fatty liver is associated with lipid accumulation in hepatocytes, leading to …