From antibiotic to antiviral: computational screening reveals a multi-targeting antibiotic from Streptomyces spp. against Nipah virus fusion proteins

NMO Odchimar, MAB Macalalad, FL Orosco - Molecular Diversity, 2024 - Springer
Nipah Virus is a re-emerging zoonotic paramyxovirus that poses a significant threat to both
swine industry and human health. The pursuit of potential antiviral agents with both …

Cytotoxicity of a new spiro-acridine derivative: Modulation of cellular antioxidant state and induction of cell cycle arrest and apoptosis in HCT-116 colorectal carcinoma

VM de Sousa, SS Duarte, DKF Silva… - Naunyn-Schmiedeberg's …, 2024 - Springer
Colorectal cancer (CRC) ranks as the third most common primary malignancy.
Epidemiological data projected approximately 1.9 million new cases and 0.9 million deaths …

[HTML][HTML] Iso-mukaadial acetate and ursolic acid acetate inhibit the chaperone activity of Plasmodium falciparum heat shock protein 70-1

N Salomane, OJ Pooe, MBC Simelane - Cell Stress and Chaperones, 2021 - Elsevier
Plasmodium falciparum is the most lethal malaria parasite. The present study investigates
the interaction capabilities of select plant derivatives, iso-mukaadial acetate (IMA) and …

Neuroprotective effects of cerebroprotein hydrolysate and its combination with antioxidants against oxidative stress-induced HT22 cell death

EJ Yang, JC Kim, DH Na - Toxicological Research, 2024 - Springer
This study aimed to investigate the neuroprotective effects of cerebroprotein hydrolysate
(CPH) against oxidative stress-induced HT22 cell death. Additionally, the effect of …

Role of target fishing in Discovery of Novel Anti-alzheimer's agents: in Silico Applications

A Murmu, BW Matore, P Banjare, NK Pandey… - Deciphering drug targets …, 2023 - Springer
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by
progressive degeneration in the brain and shrinking (atrophy) of the brain size with the …

A drug repurposing endeavor to discover a multi-targeting ligand against RhlR and LasR proteins from opportunistic human pathogen Pseudomonas aeruginosa

N Chowdhury, A Bagchi - Journal of Molecular Modeling, 2022 - Springer
Pseudomonas aeruginosa is an opportunistic human pathogen. It synthesizes the poison
called Hydrogen Cyanide (HCN). The synthesis of HCN is mediated by the enzyme HCN …

Insights on a new sulfonamide chalcone with potential antineoplastic application

PRS Wenceslau, RLG de Paula, VS Duarte… - Journal of Molecular …, 2021 - Springer
Abstract Chalcones (E)-1, 3-diphenyl-2-propene-1-ones, a class of biosynthetic precursor
molecules of flavonoids, have a wide variety of biological applications. Besides the natural …

A structure-based virtual high-throughput screening, molecular docking, molecular dynamics and MM/PBSA study identified novel putative drug-like dual inhibitors of …

C Eurtivong, C Zimmer, T Schirmeister, C Butkinaree… - Molecular Diversity, 2024 - Springer
Virtual screening a collection of~ 25,000 ChemBridge molecule collection identified two
nitrogenous heterocyclic molecules, 12 and 15, with potential dual inhibitory properties …

Trawling the Genome: Drug Target Identification in the Postgenomic Era

D Francis, TK Yadagini, R Ravindran - Drugs from Nature: Targets, Assay …, 2024 - Springer
Drug discovery is the mainstay of the pharmaceutical industry. Despite the advent of
technologies that enable a deep understanding of diseases at the molecular and …

Plant-Derived Drugs for Alzheimer's Disease and Other Neurological Disorders

B Sumithra, SK Mandal, B Mishra, K Mounika… - … of Tropical Medicinal …, 2023 - Springer
Alzheimer's disease (AD) is a progressive, debilitating neurological disorder associated with
chronic damage to neuronal cells that result in the disruption of the function and structure of …