Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview
M Dhameja, P Gupta - European journal of medicinal chemistry, 2019 - Elsevier
Abstract α-Glucosidase enzyme inhibition is an effective therapeutic decorum in the
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
Synthesis, DFT studies, molecular docking and biological activity evaluation of thiazole-sulfonamide derivatives as potent Alzheimer's inhibitors
Alzheimer's disease is a major public brain condition that has resulted in many deaths, as
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
Bio-oriented synthesis of novel (S)-flurbiprofen clubbed hydrazone schiff's bases for diabetic management: In vitro and in silico studies
A new series of (S)-flurbiprofen derivatives 4a–4p and 5a–5n were synthesized with different
aromatic or aliphatic aldehydes and ketones to produce Schiff's bases and their structures …
aromatic or aliphatic aldehydes and ketones to produce Schiff's bases and their structures …
Novel flurbiprofen clubbed oxadiazole derivatives as potential urease inhibitors and their molecular docking study
In this study, twenty eight novel oxadiazole derivatives (5–32) of the marketed available non-
steroidal anti-inflammatory drug (NSAID),(S)-flurbiprofen (1), were synthesized via I2 …
steroidal anti-inflammatory drug (NSAID),(S)-flurbiprofen (1), were synthesized via I2 …
Synthesis, in vitro evaluation and molecular docking studies of novel triazine-triazole derivatives as potential α-glucosidase inhibitors
G Wang, Z Peng, J Wang, X Li, J Li - European journal of medicinal …, 2017 - Elsevier
A novel series of triazine-triazole derivatives 7a–7m were synthesized, characterized by 1 H
NMR and evaluated for their α-glucosidase inhibitory activity. All the synthesized …
NMR and evaluated for their α-glucosidase inhibitory activity. All the synthesized …
Carbazoles: role and functions in fighting diabetes
Carbazole derivatives have gained a lot of attention in medicinal chemistry over the last few
decades due to their wide range of biological and pharmacological properties, including …
decades due to their wide range of biological and pharmacological properties, including …
Bio-oriented synthesis of novel polyhydroquinoline derivatives as α-glucosidase inhibitor for management of diabetes
Polyhydroquinoline derivatives (1-15) were synthesized through an unsymmetrical Hantzsch
reaction in excellent yields by treating 3, 5-dibromo-4-hydroxybenzaldehyde, dimedone …
reaction in excellent yields by treating 3, 5-dibromo-4-hydroxybenzaldehyde, dimedone …
Synthesis, biological evaluation and molecular docking study of benzimidazole derivatives as α-glucosidase inhibitors and anti-diabetes candidates
Voglibose and acarbose are distinguished α-glucosidase inhibitors used for controlling
diabetes mellitus. Unfortunately, these distinguished and clinically used inhibitors have also …
diabetes mellitus. Unfortunately, these distinguished and clinically used inhibitors have also …
Thiadiazole based triazole/hydrazone derivatives: Synthesis, in vitro α-glucosidase inhibitory activity and in silico molecular docking study
Thiadiazole-based hydrazide was treated with different substituted phenyl isothiocyanates
and benzaldehyde to synthesize thiadiazole-based triazole/hydrazone derivatives (4a–h & …
and benzaldehyde to synthesize thiadiazole-based triazole/hydrazone derivatives (4a–h & …
Synthesis, molecular docking, acetylcholinesterase and butyrylcholinesterase inhibitory potential of thiazole analogs as new inhibitors for Alzheimer disease
A series of thirty (30) thiazole analogs were prepared, characterized by 1 H NMR, 13 C NMR
and EI-MS and evaluated for Acetylcholinesterase and butyrylcholinesterase inhibitory …
and EI-MS and evaluated for Acetylcholinesterase and butyrylcholinesterase inhibitory …