Prostaglandins are formed from arachidonic acid by the action of cyclooxygenase and
subsequent downstream synthetases. Two closely related forms of the cyclooxygenase have …

Abstract Cyclooxygenase2 (COX-2), an inducible prostaglandin G/H synthase, is
overexpressed in several human cancers. Here, the potential utility of selective COX-2 …

Inflammation involves the sequential activation of signaling pathways leading to the
production of both pro-and anti-inflammatory mediators. Although much attention has …

Sulforaphane (SFN), an aliphatic isothiocyanate, is a known cancer chemopreventive agent.
Aiming to investigate anti-inflammatory mechanisms of SFN, we here report a potent …

Uncontrolled inflammatory processes are at the root of numerous pathologies. Most recently,
studies on confirmed COVID-19 cases have suggested that mortality might be due to virally …

The cyclooxygenase (COX, prostaglandin endoperoxide synthase) is a key enzyme in
prostaglandin biosynthesis. Two isoforms of COX, COX-1 and COX-2, have been identified …

Luteolin, a plant flavonoid, has potent anti-inflammatory properties both in vitro and in vivo.
However, the molecular mechanism of luteolin-mediated immune modulation has not been …

Objectives: To provide an overview on: 1) the expression of cyclooxygenase (COX)-2 in
articular tissues; 2) the role of prostaglandin E2 (PGE2) in these tissue functions; and 3) …

Cyclooxygenases (COX) play an important role in lipid signaling by oxygenating arachidonic
acid to endoperoxide precursors of prostaglandins and thromboxane. Two cyclooxygenases …

Sauchinone, a lignan isolated from Saururus chinensis (Saururaceae), is a diastereomeric
lignan with cytoprotective and antioxidant activities in cultured hepatocytes. The effects of …