Wilms tumour (WT) is a childhood embryonal tumour that is paradigmatic of the intersection
between disrupted organogenesis and tumorigenesis. Many WT genes play a critical (non …

Low bone mass and strength lead to fragility fractures, for example, in elderly individuals
affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare …

Aberrant regulation of the Wnt signaling pathway is a prevalent theme in cancer biology.
From the earliest observation that Wnt overexpression could lead to malignant …

For more than a decade, Wnt signaling pathways have been the focus of intense research
activity in bone biology laboratories because of their importance in skeletal development …

Sirt1, the mammalian ortholog of the yeast Sir2 (silent information regulator 2), was shown to
play an important role in metabolism and in age-associated diseases, but its role in skeletal …

The modern study of Wilms tumour was prompted nearly 50 years ago, when Alfred
Knudson proposed the 'two-hit'model of tumour development. Since then, the efforts of …

Wilms' tumor, or nephroblastoma, is the most common pediatric renal cancer. The tumors
morphologically resemble embryonic kidneys with a disrupted architecture and are …

WTX is a tumor suppressor protein that is lost or mutated in up to 30% of cases of Wilms
tumor. Among its known functions, WTX interacts with the β-transducin repeat containing …

Wilms tumors (WT) have provided broad insights into the interface between development
and tumorigenesis. Further understanding is confounded by their genetic, histologic, and …

Wilms tumor gene on the X chromosome (WTX) is a putative tumor suppressor gene in
Wilms tumor, but its expression and functions in other tumors are unclear. Colorectal cancer …