Abstract Structure and function are highly correlated in the vertebrate retina, a sensory tissue
that is organized into cell layers with microcircuits working in parallel and together to encode …

Retinitis pigmentosa (RP) is an inherited retinal dystrophy caused by the loss of
photoreceptors and characterized by retinal pigment deposits visible on fundus examination …

Oxidative stress contributes to the loss of neurons in many disease conditions as well as
during normal aging; however, small-molecule agents that reduce oxidation have not been …

Mammalian retinal degenerations initiated by gene defects in rods, cones or the retinal
pigmented epithelium (RPE) often trigger loss of the sensory retina, effectively leaving the …

Retinitis pigmentosa is an incurable retinal disease that leads to blindness. One puzzling
aspect concerns the progression of the disease. Although most mutations that cause retinitis …

Many photoreceptor degenerations initially affect rods, secondarily leading to cone death. It
has long been assumed that the surviving neural retina is largely resistant to this sensory …

Restoring vision to the blind by retinal repair has been a dream of medicine for centuries,
and the first successful procedures have recently been performed. Although we are still far …

Retinitis pigmentosa (RP) is an inherited condition that features degeneration of rod and
cone photoreceptors. In all forms of RP, the genetic mutation is expressed exclusively in …

Leber congenital amaurosis is a congenital retinal dystrophy described almost 150 years
ago. Today, Leber congenital amaurosis is proving instrumental in our understanding of the …

The relative rate of rod and cone degeneration is a fundamental characteristic of any
disorder affecting photoreceptors, including ageing and age-related maculopathy (ARM) …