DNA double-strand breaks (DSBs) are highly cytotoxic DNA lesions. The swift recognition
and faithful repair of such damage is crucial for the maintenance of genomic stability, as well …

Post-translational modifications such as ubiquitination play important regulatory roles in
several biological processes in eukaryotes. This process could be reversed by …

The DNA damage response (DDR) is critical for maintaining cellular homeostasis and
genome integrity. Mounting evidence has shown that posttranslational protein modifications …

Deubiquitylating enzymes (DUBs) maintain relative homeostasis of the cellular ubiquitome
by removing the post‐translational modification ubiquitin moiety from substrates. Numerous …

Ubiquitination represents a post-translational modification (PTM) essential for the
maintenance of cellular homeostasis. Ubiquitination is involved in the regulation of protein …

The addition of mono-ubiquitin or poly-ubiquitin chain to signaling proteins in response to
DNA damage signal is thought to be a critical event that facilitates the recognition of DNA …

DNA double-strand break repair by homologous recombination entails the resection of DNA
ends to reveal ssDNA tails, which are used to invade a homologous DNA template. CtIP and …

Abstract Poly-(ADP-ribose) polymerase inhibitors (PARPi) selectively kill breast and ovarian
cancers with defects in homologous recombination (HR) caused by BRCA1/2 mutations …

Homologous recombination (HR) is one of the major DNA double-strand break (DSB) repair
pathways in mammalian cells. Defects in HR trigger genomic instability and result in cancer …

Both proteolytic and nonproteolytic functions of ubiquitination are essential regulatory
mechanisms for promoting DNA repair and the DNA damage response in mammalian cells …