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[HTML][HTML] HRP2: transforming malaria diagnosis, but with caveats
The major growth in point-of-care malaria diagnosis over the past decade has been based
on immunochromatographic malaria rapid diagnostic tests (mRDTs), which generally detect …
on immunochromatographic malaria rapid diagnostic tests (mRDTs), which generally detect …
Systematic review of the status of pfhrp2 and pfhrp3 gene deletion, approaches and methods used for its estimation and reporting in Plasmodium falciparum …
BB Agaba, A Yeka, S Nsobya, E Arinaitwe… - Malaria journal, 2019 - Springer
Background Malaria rapid diagnostic tests based on histidine-rich protein-2 have played a
vital role in improving malaria case management and surveillance particularly in Africa …
vital role in improving malaria case management and surveillance particularly in Africa …
Plasmodium falciparum is evolving to escape malaria rapid diagnostic tests in Ethiopia
SM Feleke, EN Reichert, H Mohammed… - Nature …, 2021 - nature.com
In Africa, most rapid diagnostic tests (RDTs) for falciparum malaria recognize histidine-rich
protein 2 antigen. Plasmodium falciparum parasites lacking histidine-rich protein 2 (pfhrp2) …
protein 2 antigen. Plasmodium falciparum parasites lacking histidine-rich protein 2 (pfhrp2) …
An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples
A Ahouidi, M Ali, J Almagro-Garcia… - Wellcome open …, 2021 - pmc.ncbi.nlm.nih.gov
MalariaGEN is a data-sharing network that enables groups around the world to work
together on the genomic epidemiology of malaria. Here we describe a new release of …
together on the genomic epidemiology of malaria. Here we describe a new release of …
Detection of high prevalence of Plasmodium falciparum histidine-rich protein 2/3 gene deletions in Assosa zone, Ethiopia: implication for malaria diagnosis
GS Alemayehu, K Blackburn, K Lopez… - Malaria journal, 2021 - Springer
Abstract Background Rapid diagnostic tests (RDTs) targeting histidine rich protein 2 (HRP2)
are widely used for diagnosis of Plasmodium falciparum infections. Besides PfHRP2, the …
are widely used for diagnosis of Plasmodium falciparum infections. Besides PfHRP2, the …
A novel multiplex qPCR assay for detection of Plasmodium falciparum with histidine-rich protein 2 and 3 (pfhrp2 and pfhrp3) deletions in polyclonal infections
Background Many health facilities in malaria endemic countries are dependent on Rapid
diagnostic tests (RDTs) for diagnosis and some National Health Service (NHS) hospitals …
diagnostic tests (RDTs) for diagnosis and some National Health Service (NHS) hospitals …
Widespread pfhrp2/3 deletions and HRP2-based false-negative results in southern Ethiopia
B Mekonen, S Dugassa, SM Feleke, B Dufera, B Gidisa… - Malaria Journal, 2024 - Springer
Abstract Background Rapid diagnostic tests (RDTs) play a significant role in expanding case
management in peripheral healthcare systems. Histidine-rich protein-2 (HRP2) antigen …
management in peripheral healthcare systems. Histidine-rich protein-2 (HRP2) antigen …
Emergence of artemisinin-based combination treatment failure in patients returning from sub-Saharan Africa with P. falciparum malaria
T Grossman, J Vainer, Y Paran… - Journal of Travel …, 2023 - academic.oup.com
Background Artemisinin-based combination therapies (ACTs) are recommended as first-line
treatment against uncomplicated Plasmodium falciparum infection. Mutations in the …
treatment against uncomplicated Plasmodium falciparum infection. Mutations in the …
Analysis of false-negative rapid diagnostic tests for symptomatic malaria in the Democratic Republic of the Congo
The majority of Plasmodium falciparum malaria diagnoses in Africa are made using rapid
diagnostic tests (RDTs) that detect histidine-rich protein 2. Increasing reports of false …
diagnostic tests (RDTs) that detect histidine-rich protein 2. Increasing reports of false …
Prevalence of Plasmodium falciparum field isolates with deletions in histidine-rich protein 2 and 3 genes in context with sub-Saharan Africa and India: a systematic …
LP Kojom, V Singh - Malaria journal, 2020 - Springer
Abstract Background In 2017, nearly 80% of malaria morbidity and mortality occurred in sub-
Saharan African (SSA) countries and India. Rapid diagnostic tests (RDTs), especially those …
Saharan African (SSA) countries and India. Rapid diagnostic tests (RDTs), especially those …