Engineering bacteria as interactive cancer therapies

CR Gurbatri, N Arpaia, T Danino - Science, 2022 - science.org
With increasing evidence that microbes colonize tumors, synthetic biology tools are being
leveraged to repurpose bacteria as tumor-specific delivery systems. These engineered …

Protein-based biological materials: molecular design and artificial production

A Miserez, J Yu, P Mohammadi - Chemical reviews, 2023 - ACS Publications
Polymeric materials produced from fossil fuels have been intimately linked to the
development of industrial activities in the 20th century and, consequently, to the …

Principles of genetic circuit design

JAN Brophy, CA Voigt - Nature methods, 2014 - nature.com
Cells navigate environments, communicate and build complex patterns by initiating gene
expression in response to specific signals. Engineers seek to harness this capability to …

Designing cell function: assembly of synthetic gene circuits for cell biology applications

M **e, M Fussenegger - Nature Reviews Molecular Cell Biology, 2018 - nature.com
Synthetic biology is the discipline of engineering application-driven biological functionalities
that were not evolved by nature. Early breakthroughs of cell engineering, which were based …

Synthetic biology: applications come of age

AS Khalil, JJ Collins - Nature Reviews Genetics, 2010 - nature.com
Synthetic biology is bringing together engineers and biologists to design and build novel
biomolecular components, networks and pathways, and to use these constructs to rewire …

Synthesis and patterning of tunable multiscale materials with engineered cells

AY Chen, Z Deng, AN Billings, UOS Seker, MY Lu… - Nature materials, 2014 - nature.com
Many natural biological systems—such as biofilms, shells and skeletal tissues—are able to
assemble multifunctional and environmentally responsive multiscale assemblies of living …

Bacterial type III secretion systems: a complex device for the delivery of bacterial effector proteins into eukaryotic host cells

S Wagner, I Grin, S Malmsheimer… - FEMS microbiology …, 2018 - academic.oup.com
Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial
effector proteins into eukaryotic host cells. They are able to secrete a great diversity of …

Native-sized recombinant spider silk protein produced in metabolically engineered Escherichia coli results in a strong fiber

XX **a, ZG Qian, CS Ki, YH Park, DL Kaplan… - Proceedings of the …, 2010 - pnas.org
Spider dragline silk is a remarkably strong fiber that makes it attractive for numerous
applications. Much has thus been done to make similar fibers by biomimic spinning of …

Type III secretion systems: the bacterial flagellum and the injectisome

A Diepold, JP Armitage - Philosophical Transactions of …, 2015 - royalsocietypublishing.org
The flagellum and the injectisome are two of the most complex and fascinating bacterial
nanomachines. At their core, they share a type III secretion system (T3SS), a transmembrane …

DCEO biotechnology: tools to design, construct, evaluate, and optimize the metabolic pathway for biosynthesis of chemicals

X Chen, C Gao, L Guo, G Hu, Q Luo, J Liu… - Chemical …, 2018 - ACS Publications
Chemical synthesis is a well established route for producing many chemicals on a large
scale, but some drawbacks still exist in this process, such as unstable intermediates …