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Engineering bacteria as interactive cancer therapies
With increasing evidence that microbes colonize tumors, synthetic biology tools are being
leveraged to repurpose bacteria as tumor-specific delivery systems. These engineered …
leveraged to repurpose bacteria as tumor-specific delivery systems. These engineered …
Protein-based biological materials: molecular design and artificial production
Polymeric materials produced from fossil fuels have been intimately linked to the
development of industrial activities in the 20th century and, consequently, to the …
development of industrial activities in the 20th century and, consequently, to the …
Principles of genetic circuit design
Cells navigate environments, communicate and build complex patterns by initiating gene
expression in response to specific signals. Engineers seek to harness this capability to …
expression in response to specific signals. Engineers seek to harness this capability to …
Designing cell function: assembly of synthetic gene circuits for cell biology applications
M **e, M Fussenegger - Nature Reviews Molecular Cell Biology, 2018 - nature.com
Synthetic biology is the discipline of engineering application-driven biological functionalities
that were not evolved by nature. Early breakthroughs of cell engineering, which were based …
that were not evolved by nature. Early breakthroughs of cell engineering, which were based …
Synthetic biology: applications come of age
Synthetic biology is bringing together engineers and biologists to design and build novel
biomolecular components, networks and pathways, and to use these constructs to rewire …
biomolecular components, networks and pathways, and to use these constructs to rewire …
Synthesis and patterning of tunable multiscale materials with engineered cells
Many natural biological systems—such as biofilms, shells and skeletal tissues—are able to
assemble multifunctional and environmentally responsive multiscale assemblies of living …
assemble multifunctional and environmentally responsive multiscale assemblies of living …
Bacterial type III secretion systems: a complex device for the delivery of bacterial effector proteins into eukaryotic host cells
Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial
effector proteins into eukaryotic host cells. They are able to secrete a great diversity of …
effector proteins into eukaryotic host cells. They are able to secrete a great diversity of …
Native-sized recombinant spider silk protein produced in metabolically engineered Escherichia coli results in a strong fiber
Spider dragline silk is a remarkably strong fiber that makes it attractive for numerous
applications. Much has thus been done to make similar fibers by biomimic spinning of …
applications. Much has thus been done to make similar fibers by biomimic spinning of …
Type III secretion systems: the bacterial flagellum and the injectisome
The flagellum and the injectisome are two of the most complex and fascinating bacterial
nanomachines. At their core, they share a type III secretion system (T3SS), a transmembrane …
nanomachines. At their core, they share a type III secretion system (T3SS), a transmembrane …
DCEO biotechnology: tools to design, construct, evaluate, and optimize the metabolic pathway for biosynthesis of chemicals
Chemical synthesis is a well established route for producing many chemicals on a large
scale, but some drawbacks still exist in this process, such as unstable intermediates …
scale, but some drawbacks still exist in this process, such as unstable intermediates …