Analysis of nanoparticle delivery to tumours
Targeting nanoparticles to malignant tissues for improved diagnosis and therapy is a
popular concept. However, after surveying the literature from the past 10 years, only …
popular concept. However, after surveying the literature from the past 10 years, only …
Targeting tumor-associated macrophages to synergize tumor immunotherapy
X **ang, J Wang, D Lu, X Xu - Signal transduction and targeted therapy, 2021 - nature.com
The current treatment strategies in advanced malignancies remain limited. Notably,
immunotherapies have raised hope for a successful control of these advanced diseases, but …
immunotherapies have raised hope for a successful control of these advanced diseases, but …
Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination
99% of administered nanoparticles will accumulate and sequester in the liver after
administration into the body. This results in reduced delivery to the targeted diseased tissue …
administration into the body. This results in reduced delivery to the targeted diseased tissue …
Mesenchymal stem cell-macrophage crosstalk and bone healing
Recent research has brought about a clear understanding that successful fracture healing is
based on carefully coordinated cross-talk between inflammatory and bone forming cells. In …
based on carefully coordinated cross-talk between inflammatory and bone forming cells. In …
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
GL Beatty, EG Chiorean, MP Fishman, B Saboury… - Science, 2011 - science.org
Immunosuppressive tumor microenvironments can restrain antitumor immunity, particularly
in pancreatic ductal adenocarcinoma (PDA). Because CD40 activation can reverse immune …
in pancreatic ductal adenocarcinoma (PDA). Because CD40 activation can reverse immune …
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
Healing of myocardial infarction (MI) requires monocytes/macrophages. These mononuclear
phagocytes likely degrade released macromolecules and aid in scavenging of dead …
phagocytes likely degrade released macromolecules and aid in scavenging of dead …
Progress in tumor-associated macrophage (TAM)-targeted therapeutics
As an essential innate immune population for maintaining body homeostasis and warding
off foreign pathogens, macrophages display high plasticity and perform diverse supportive …
off foreign pathogens, macrophages display high plasticity and perform diverse supportive …
Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation
A defining feature of inflammation is the accumulation of innate immune cells in the tissue
that are thought to be recruited from the blood. We reveal that a distinct process exists in …
that are thought to be recruited from the blood. We reveal that a distinct process exists in …
Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis
L Arnold, A Henry, F Poron, Y Baba-Amer… - The Journal of …, 2007 - rupress.org
Macrophages (MPs) are important for skeletal muscle regeneration in vivo and may exert
beneficial effects on myogenic cell growth through mitogenic and antiapoptotic activities in …
beneficial effects on myogenic cell growth through mitogenic and antiapoptotic activities in …