Targeting tumor-associated macrophages to synergize tumor immunotherapy
X **ang, J Wang, D Lu, X Xu - Signal transduction and targeted therapy, 2021 - nature.com
The current treatment strategies in advanced malignancies remain limited. Notably,
immunotherapies have raised hope for a successful control of these advanced diseases, but …
immunotherapies have raised hope for a successful control of these advanced diseases, but …
Why nanoparticles prefer liver macrophage cell uptake in vivo
Effective delivery of therapeutic and diagnostic nanoparticles is dependent on their ability to
accumulate in diseased tissues. However, most nanoparticles end up in liver macrophages …
accumulate in diseased tissues. However, most nanoparticles end up in liver macrophages …
Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function
In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …
Elimination pathways of nanoparticles
Understanding how nanoparticles are eliminated from the body is required for their
successful clinical translation. Many promising nanoparticle formulations for in vivo medical …
successful clinical translation. Many promising nanoparticle formulations for in vivo medical …
Symbiotic Firmicutes establish mutualism with the host via innate tolerance and resistance to control systemic immunity
CKI Jordan, RL Brown, MLY Larkinson, RP Sequeira… - Cell Host & Microbe, 2023 - cell.com
The intestinal microbiota regulates immunity across organ systems. Which symbionts control
systemic immunity, the mechanisms they use, and how they avoid widespread inflammatory …
systemic immunity, the mechanisms they use, and how they avoid widespread inflammatory …
Mesenchymal stem cell-macrophage crosstalk and bone healing
Recent research has brought about a clear understanding that successful fracture healing is
based on carefully coordinated cross-talk between inflammatory and bone forming cells. In …
based on carefully coordinated cross-talk between inflammatory and bone forming cells. In …
Harnessing anti‐tumor and tumor‐tropism functions of macrophages via nanotechnology for tumor immunotherapy
Y Zheng, Y Han, Q Sun, Z Li - Exploration, 2022 - Wiley Online Library
Reprogramming the immunosuppressive tumor microenvironment by modulating
macrophages holds great promise in tumor immunotherapy. As a class of professional …
macrophages holds great promise in tumor immunotherapy. As a class of professional …
Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis
P An, LL Wei, S Zhao, DY Sverdlov, KA Vaid… - Nature …, 2020 - nature.com
Due to their bacterial ancestry, many components of mitochondria share structural
similarities with bacteria. Release of molecular danger signals from injured cell mitochondria …
similarities with bacteria. Release of molecular danger signals from injured cell mitochondria …
Analysis of nanoparticle delivery to tumours
Targeting nanoparticles to malignant tissues for improved diagnosis and therapy is a
popular concept. However, after surveying the literature from the past 10 years, only …
popular concept. However, after surveying the literature from the past 10 years, only …
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine
Tryptophan catabolism by the enzymes indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-
dioxygenase 2 (IDO/TDO) promotes immunosuppression across different cancer types. The …
dioxygenase 2 (IDO/TDO) promotes immunosuppression across different cancer types. The …