I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …

Aging is a major risk factor for many diseases including metabolic syndrome, cancer,
inflammation, and neurodegeneration. Identifying mechanistic common denominators …

The notion of “immune privilege” of the brain has been revised to accommodate its
infiltration, at steady state, by immune cells that participate in normal neurophysiology …

T cells clear virus from the CNS and dynamically regulate brain functions, including spatial
learning, through cytokine signaling. Here we determined whether hippocampal T cells that …

Hippocampal neurogenesis continues throughout life and has been suggested to play an
essential role in maintaining spatial cognitive function under physiological conditions. An …

Neuroinflammation in patients with Alzheimer's disease (AD) and related mouse models has
been recognized for decades, but the contribution of the recently described meningeal …

Neuroinflammation driven by interferon‐gamma (IFN‐γ) and microglial activation has been
linked to neurological disease. However, the effects of IFN‐γ‐activated microglia on …

Many genetic and environmental factors increase susceptibility to cognitive impairment (CI),
and the gut microbiome is increasingly implicated. However, the identity of gut microbes …

The mechanisms of communication between the brain and the immune cells are still largely
unclear. Here, we characterize the populations of resident natural killer (NK) cells and innate …

Recently, the roles of inflammation and insulin resistance in neurodegeneration have
become better appreciated. NE3107, an oral small molecule, blood-brain permeable anti …