The uridine diphosphoglucuronosyltransferases (UGTs) belong to a superfamily of enzymes
that catalyse the glucuronidation of numerous endobiotics and xenobiotics. Several human …

Nicotine is the psychoactive substance responsible for tobacco dependence. It is also a
therapeutic used to aid smoking cessation. Cytochrome P450 (CYP) 2A6 is the human …

Lamotrigine (LTG) which has a widespread use in epilepsy treatment as an antiepileptic
agent is metabolized by UDP-glucuronosyl transferase (UGT) enzymes. In this study, single …

Nicotine has roles in the addiction to smoking, replacement therapy for smoking cessation,
as a potential medication for several diseases such as Parkinson's disease, Alzheimer's …

The monitoring of plasma olanzapine concentrations has been found to be an important and
useful tool for optimizing psychiatric treatment. The present study investigated the effect that …

Patients treated with antiepileptic drugs can exhibit large interindividual variability in clinical
efficacy or adverse effects. This could be partially due to genetic variants in genes coding for …

Background Lamotrigine is an antiseizure drug (ASD) which was approved by the US Food
and Drug Administration in 1994 to treat focal (partial) seizures, primary generalized tonic …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Anastrozole is primarily cleared by
hepatic metabolism via oxidative and conjugating enzymes. WHAT THIS STUDY ADDS• …

The substrate spectrum of human UDP-glucuronosyltransferase 1A (UGT1A) proteins
includes the glucuronidation of non-steroidal anti-inflammatory drugs, anticonvulsants …

Objective The pharmacokinetics of lamotrigine (LTG) varies significantly among individuals
and particularly among different ethnic groups. This is in part due to the presence of genetic …