Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

Cholesterol has been conjectured to be a modulator of the amyloid cascade, the mechanism
that produces the amyloid-β (Aβ) peptides implicated in the onset of Alzheimer's disease …

▪ Abstract Stably folded membrane proteins reside in a free energy minimum determined by
the interactions of the peptide chains with each other, the lipid bilayer hydrocarbon core, the …

Helical integral membrane proteins share several structural determinants that are widely
conserved across their universe. The discovery of common motifs has furthered our …

Polar residues in transmembrane α-helices may strongly influence the folding or association
of integral membrane proteins. To test whether a motif that promotes helix association in a …

Specific helix–helix interactions inside lipid bilayers guide the folding and assembly of many
integral membrane proteins and their complexes. We report here a pattern of 7 amino acids …

A simple extension of the EEF1 energy function to heterogeneous membrane‐aqueous
media is proposed. The extension consists of (a) development of solvation parameters for a …

A survey of 45 transmembrane (TM) helices and 88 helix packing interactions in three
independent transmembrane protein structures reveals the following features.(1) Helix …

While a considerable amount of literature deals with the structural energetics of water-
soluble proteins, relatively little is known about the forces that determine the stability of …

Studies of the dimerization of transmembrane (TM) helices have been ongoing for many
years now, and have provided clues to the fundamental principles behind membrane protein …