A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium

W Checkley, AC White, D Jaganath… - The Lancet Infectious …, 2015 - thelancet.com
Cryptosporidium spp are well recognised as causes of diarrhoeal disease during
waterborne epidemics and in immunocompromised hosts. Studies have also drawn …

Cryptosporidium and cryptosporidiosis

RCA Thompson, ME Olson, G Zhu, S Enomoto… - Advances in …, 2005 - Elsevier
Cryptosporidium is one of the most common enteric protozoan parasites of vertebrates with
a wide host range that includes humans and domestic animals. It is a significant cause of …

[KÖNYV][B] Evolution through genetic exchange

ML Arnold - 2006 - books.google.com
Even before the publication of Darwin's Origin of Species, the perception of evolutionary
change has been a tree-like pattern of diversification-with divergent branches spreading …

Sequencing of the smallest Apicomplexan genome from the human pathogen Babesia microti

E Cornillot, K Hadj-Kaddour, A Dassouli… - Nucleic acids …, 2012 - academic.oup.com
We have sequenced the genome of the emerging human pathogen Babesia microti and
compared it with that of other protozoa. B. microti has the smallest nuclear genome among …

Phylogenomic evidence supports past endosymbiosis, intracellular and horizontal gene transfer in Cryptosporidium parvum

J Huang, N Mullapudi, CA Lancto, M Scott… - Genome biology, 2004 - Springer
Abstract Background The apicomplexan parasite Cryptosporidium parvum is an emerging
pathogen capable of causing illness in humans and other animals and death in …

An update on Cryptosporidium biology and therapeutic avenues

AK Dhal, C Panda, SIL Yun, RK Mahapatra - Journal of Parasitic Diseases, 2022 - Springer
Cryptosporidium species has been identified as an important pediatric diarrheal pathogen in
resource-limited countries, particularly in very young children (0–24 months). However, the …

Lactate dehydrogenase and malate dehydrogenase: Potential antiparasitic targets for drug development studies

F Kayamba, M Faya, OJ Pooe, B Kushwaha… - Bioorganic & Medicinal …, 2021 - Elsevier
Parasitic diseases remain a major public health concern for humans, claiming millions of
lives annually. Although different treatments are required for these diseases, drug usage is …

Activity, stability and structural studies of lactate dehydrogenases adapted to extreme thermal environments

N Coquelle, E Fioravanti, M Weik, F Vellieux… - Journal of Molecular …, 2007 - Elsevier
Lactate dehydrogenase (LDH) catalyzes the conversion of pyruvate to lactate with
concomitant oxidation of NADH during the last step in anaerobic glycolysis. In the present …

An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases

JI Boucher, JR Jacobowitz, BC Beckett, S Classen… - Elife, 2014 - elifesciences.org
Malate and lactate dehydrogenases (MDH and LDH) are homologous, core metabolic
enzymes that share a fold and catalytic mechanism yet possess strict specificity for their …

Deciphering evolutionary trajectories of lactate dehydrogenases provides new insights into allostery

AY Robin, C Brochier-Armanet… - Molecular Biology …, 2023 - academic.oup.com
Abstract Lactate dehydrogenase (LDH, EC. 1.1. 127) is an important enzyme engaged in the
anaerobic metabolism of cells, catalyzing the conversion of pyruvate to lactate and NADH to …