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A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium
Cryptosporidium spp are well recognised as causes of diarrhoeal disease during
waterborne epidemics and in immunocompromised hosts. Studies have also drawn …
waterborne epidemics and in immunocompromised hosts. Studies have also drawn …
Cryptosporidium and cryptosporidiosis
RCA Thompson, ME Olson, G Zhu, S Enomoto… - Advances in …, 2005 - Elsevier
Cryptosporidium is one of the most common enteric protozoan parasites of vertebrates with
a wide host range that includes humans and domestic animals. It is a significant cause of …
a wide host range that includes humans and domestic animals. It is a significant cause of …
[KÖNYV][B] Evolution through genetic exchange
ML Arnold - 2006 - books.google.com
Even before the publication of Darwin's Origin of Species, the perception of evolutionary
change has been a tree-like pattern of diversification-with divergent branches spreading …
change has been a tree-like pattern of diversification-with divergent branches spreading …
Sequencing of the smallest Apicomplexan genome from the human pathogen Babesia microti
E Cornillot, K Hadj-Kaddour, A Dassouli… - Nucleic acids …, 2012 - academic.oup.com
We have sequenced the genome of the emerging human pathogen Babesia microti and
compared it with that of other protozoa. B. microti has the smallest nuclear genome among …
compared it with that of other protozoa. B. microti has the smallest nuclear genome among …
Phylogenomic evidence supports past endosymbiosis, intracellular and horizontal gene transfer in Cryptosporidium parvum
J Huang, N Mullapudi, CA Lancto, M Scott… - Genome biology, 2004 - Springer
Abstract Background The apicomplexan parasite Cryptosporidium parvum is an emerging
pathogen capable of causing illness in humans and other animals and death in …
pathogen capable of causing illness in humans and other animals and death in …
An update on Cryptosporidium biology and therapeutic avenues
Cryptosporidium species has been identified as an important pediatric diarrheal pathogen in
resource-limited countries, particularly in very young children (0–24 months). However, the …
resource-limited countries, particularly in very young children (0–24 months). However, the …
Lactate dehydrogenase and malate dehydrogenase: Potential antiparasitic targets for drug development studies
Parasitic diseases remain a major public health concern for humans, claiming millions of
lives annually. Although different treatments are required for these diseases, drug usage is …
lives annually. Although different treatments are required for these diseases, drug usage is …
Activity, stability and structural studies of lactate dehydrogenases adapted to extreme thermal environments
Lactate dehydrogenase (LDH) catalyzes the conversion of pyruvate to lactate with
concomitant oxidation of NADH during the last step in anaerobic glycolysis. In the present …
concomitant oxidation of NADH during the last step in anaerobic glycolysis. In the present …
An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases
Malate and lactate dehydrogenases (MDH and LDH) are homologous, core metabolic
enzymes that share a fold and catalytic mechanism yet possess strict specificity for their …
enzymes that share a fold and catalytic mechanism yet possess strict specificity for their …
Deciphering evolutionary trajectories of lactate dehydrogenases provides new insights into allostery
AY Robin, C Brochier-Armanet… - Molecular Biology …, 2023 - academic.oup.com
Abstract Lactate dehydrogenase (LDH, EC. 1.1. 127) is an important enzyme engaged in the
anaerobic metabolism of cells, catalyzing the conversion of pyruvate to lactate and NADH to …
anaerobic metabolism of cells, catalyzing the conversion of pyruvate to lactate and NADH to …