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CFD-PK model for nasal suspension sprays: Validation with human adult in vivo data for triamcinolone acetonide

R Dutta, AV Kolanjiyil, RL Walenga, SG Chopski… - International Journal of …, 2024 - Elsevier
The objectives of this study were to expand and implement a Computational Fluid Dynamics
(CFD)-Dissolution, Absorption and Clearance (DAC)-Pharmacokinetics (PK) multi-physics …
Запазване Позоваване С позовавания в 2 Сродни статии Всички 3 версии

Anatomically-detailed segmented representative adult and pediatric nasal models for assessing regional drug delivery and bioequivalence with suspension nasal …

P Khadka, M Hejazi, M Hindle, T Schuman… - International Journal of …, 2024 - Elsevier
In vitro nasal models can potentially facilitate development and approval of nasal drug
products. This study aims to evaluate the potential for using regional deposition …
Запазване Позоваване С позовавания в 1 Сродни статии Всички 2 версии

Development of a predictive model for pediatric intranasal drug delivery with nasal sprays: Leveraging intersubject variability in anatomical dimensions, administration …

M Hejazi, AM Alshammary, DJ Edwards… - Computers in Biology …, 2025 - Elsevier
In this study, we examined the correlation between anatomical dimensions, spray
administration parameters, pressure drop across 40 pediatric nasal cavities, and in vitro …
Запазване Позоваване Сродни статии Всички 2 версии