Microtubule plus-end tracking proteins (+ TIPs) are a diverse group of evolutionarily
conserved cellular factors that accumulate at the ends of growing microtubules. They form …

Eukaryotic cells use cytoskeletal motor proteins to transport many different intracellular
cargos. Numerous kinesins and myosins have evolved to cope with the various transport …

Cytoplasmic dynein is a molecular motor that transports a large variety of cargoes (eg,
organelles, messenger RNAs, and viruses) along microtubules over long intracellular …

Cytoplasmic dynein is an approximately 1.4 MDa multi‐protein complex that transports many
cellular cargoes towards the minus ends of microtubules. Several in vitro studies of …

The conversion of chemical energy into mechanical force by AAA+ (ATPases associated
with diverse cellular activities) ATPases is integral to cellular processes, including DNA …

The endocytic pathway is essential for processes that define how cells interact with their
environment, including receptor signalling, cell adhesion and migration, pathogen entry …

The microtubule motors kinesin and dynein function collectively to drive vesicular transport.
High-resolution tracking of vesicle motility in the cell indicates that transport is often …

Post‐translational modifications (PTM s) of α/β‐tubulin are believed to regulate interactions
with microtubule‐binding proteins. A well‐characterized PTM involves in the removal and re …

Cellular cargos move bidirectionally on microtubules by recruiting opposite polarity motors
dynein and kinesin. These motors show codependence, where one requires the activity of …

Dynactin is a required cofactor for the minus-end-directed microtubule motor cytoplasmic
dynein. Mutations within the highly conserved CAP-Gly domain of dynactin cause …